酵母のビタミンB_1集積ならびに生合成 : (VI) Phenylthiazinothiamineによる酵母のビタミンB_1集積阻害

概要

論文の詳細を見る
Accumulation of thiamine on cells of Saccharomyces cerevisiae was completely inhibited at the presence of phenylthiazinothiamine (PTT) but at the presence of pyrithiamine (Pyri-B_1), it was partly inhibited with its simultaneous accumulation on cells. Accumulated Pyri-B_1 was not eluted by repeated washing with saline, although the cells showed to accumulate thiamine completely after the washing with saline. Cells preincubated with PTT accumulated thiamine incompletely even after the seventh washing with saline. Thiamine accumulated on cells was washed away with PTT, not with Pyri-B_1. Yeast cells can accumulate Pyri-B_1 quickly by active transport but sparingly accumulate PTT by simple diffusion. Mode of inhibition of thiamine accumulation on yeast cells by the two inhibitors is different, although inhibitors in the medium are more important than those in cells.
日本ビタミン学会の論文
1969-11-25