Increased Production of Active Oxygen Species from Neutrophils in Streptozotocin-induced Diabetic Rat

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The production of active oxygen species from neutrophils was compared between streptozotocin (STZ)-induced diabetic rats and control rats by using a flowcytometer with 2, 7-dichlorofluorescin diacetate as an indicator.<BR>The production after stimulation with phorbol myristate acetate (PMA) was larger in neutrophils prepared from the diabetic rats than those from the control rats. On the 9th, 24th and 51st days after administration of STZ, the PMA-stimulated production of active oxygen species from neutrophils increased from the value 166.0±4.4 (before STZ) to 207.7± 4.9 (p<0.001), 24 days: 206.3±1.8, p<0.01 204.7±1.2 (p<0.05), respctively, in terms of peak channel (PC).<BR>The increased capability of diabetic neutrophils to produce active oxygen species is assumed to play a role in the metabolic disorder of diabetes.
Japan Society of Clinical Chemistryの論文