Serum Glycerophosphate Levels are Increased in Japanese Men with Type 2 Diabetes
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概要
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Objective To identify metabolites showing changes in serum levels among Japanese male with diabetes. Methods We performed metabolite profiling by coupling capillary electrophoresis with electrospray ionization time-of-flight mass spectrometry using fasting serum samples from Japanese male subjects with diabetes (n=17), impaired glucose tolerance (IGT; n=5) and normal glucose tolerance (NGT; n=14). Results Other than the expected differences in characteristics related to abnormal glucose metabolism, the percent body fat was significantly different among subjects with diabetes, IGT and NGT (27.3±6.2, 22.2±4.5 and 19.2±6.0%, respectively, p=0.0022). Therefore, percent body fat was considered as a possible confounding factor in subsequent analyses. Of 560 metabolites detected using our platform, the levels of 74 metabolites were quantified in all of the serum samples. Significant differences between diabetes and NGT were observed for 24 metabolites. The top-ranked metabolite was glycerol-3-phophate (glycerophosphate), which was significantly higher in subjects with diabetes than in those with NGT, even after Bonferroni correction for multiple testing (11.7±3.6 vs. 6.4±1.9 μM, respectively; corrected p=0.0222). Stepwise multiple regression analyses revealed that serum glycerophosphate levels were significantly correlated with 2-h plasma glucose after a 75-g oral glucose tolerance test (r=0.553, p=0.0005), independently of other characteristics, including FPG and HbA1c. Conclusion Serum glycerophosphate levels were found to be elevated in Japanese men with diabetes, and correlated with 2-h PG, independent of FPG and HbA1c. Namely, serum glycerophosphate level at fasting condition can be a marker for predicting glucose intolerance. These results warrant further studies to evaluate the relevance of glycerophosphate in the pathophysiology of diabetes.
著者
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Soga Tomoyoshi
Institute For Advanced Biosciences Keio University
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Tomita Masaru
Institute For Advanced Biosciences Keio University
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Susa Shinji
Department Of Neurology Hematology Metabolism Endocrinology And Diabetology (dnhmed) Yamagata Univer
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Wada Kiriko
Department Of Neurology Hematology Metabolism Endocrinology And Diabetology (dnhmed) Yamagata Univer
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Kameda Wataru
Department Of Neurology Hematology Metabolism Endocrinology And Diabetology (dnhmed) Yamagata Univer
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Oizumi Toshihide
Department Of Neurology Hematology Metabolism Endocrinology And Diabetology (dnhmed) Yamagata Univer
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Karasawa Shigeru
Department Of Neurology Hematology Metabolism Endocrinology And Diabetology (dnhmed) Yamagata Univer
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KAINO Wataru
Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology (DNHMED), Yamagata Un
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Kayama Takamasa
Global Center Of Excellence Program Study Group Yamagata University School Of Medicine
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Jimbu Yumi
Department Of Neurology Hematology Metabolism Endocrinology And Diabetology (dnhmed) Yamagata Univer
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Takase Kaoru
Department Of Internal Medicine And Clinical Immunology Yokohama City University Graduate School Of Medicine
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KATO Takeo
Department of Applied Physics, Osaka City University
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Daimon Makoto
Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology (DNHMED), Yamagata University School of Medicine
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Hozawa Atsushi
Department of Public Health, Yamagata University, Graduate School of Medicine, Japan
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Hozawa Atsushi
Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization
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Karasawa Shigeru
Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology (DNHMED), Yamagata University School of Medicine, Japan
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Saito Kaori
Institute for Advanced Bioscience, Keio University, Japan
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Kameda Wataru
Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology (DNHMED), Yamagata University School of Medicine, Japan
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Kaino Wataru
Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology (DNHMED), Yamagata University School of Medicine, Japan
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Daimon Makoto
Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology (DNHMED), Yamagata University School of Medicine, Japan
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Soga Tomoyoshi
Institute for Advanced Bioscience, Keio University, Japan
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Susa Shinji
Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology (DNHMED), Yamagata University School of Medicine, Japan
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Oizumi Toshihide
Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology (DNHMED), Yamagata University School of Medicine, Japan
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