The Association between Microalbuminuria and Metabolic Syndrome in the General Population in Japan: The Takahata Study
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概要
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Objective: The metabolic syndrome is associated with an increased risk of chronic kidney disease, cardiovascular disease and mortality. However, the association between microalbuminuria and the metabolic syndrome has not yet been reported in the general population in Japan. Therefore, we undertook a population-based study to examine the association between microalbuminuria and the metabolic syndrome in Takahata, Japan. Methods: Subjects of this cross-sectional study were individuals aged from 40 to 87 years old. The metabolic syndrome was defined according to the criteria of the Adult Treatment Panel III. Microalbuminuria was defined as a urine albumin-creatinine ratio of 30 to 300 mg/g. Results: A total of 2,321 subjects (mean age 64 years old) were entered into the final analysis. Among them, the prevalence of the metabolic syndrome and microalbuminuria was 16.5% and 13.7%, respectively. There was a significantly positive correlation between the number of components of the metabolic syndrome and the corresponding prevalence of microalbuminuria (p<0.001). In the subjects with metabolic syndrome compared with those without metabolic syndrome, the age- and gender-adjusted odds ratio of microalbuminuria was 1.99 (95% CI, 1.49-2.66). Multiple logistic regression analysis revealed that high glucose, high blood pressure and obesity were independently associated with microalbuminuria. Conclusions: Our study revealed a strong relationship between microalbuminuria and the metabolic syndrome in the general population in Japan. More comprehensive and intensive management of the metabolic syndrome at its early stage is important to prevent the progression of renal injury and cardiovascular complications.
著者
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Ikeda Ami
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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Hao Zhimei
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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Abiko Hiroshi
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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Ishikawa Mizue
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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Takasaki Satoshi
Department Of Cardiology Pulmonology And Nephrology ; Course Of Internal Medicine And Molecular Ther
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Ichikawa Kazunobu
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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Kawata Sumio
Department Of Biochemistry And Second Department Of Internal Medicine Osaka University Medical Schoo
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Konta Tsuneo
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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Kubota Isao
Department Of Cardiology Pulmonology And Nephrology Yamagata University Of School Of Medicine
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KATO Takeo
Department of Applied Physics, Osaka City University
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Takahashi Toshiyuki
Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University
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Takasaki Satoshi
Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine
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