Stringent Complete Remission of Primary Plasma Cell Leukemia with Reduced-dose Bortezomib, Lenalidomide and Dexamethasone: A Case Report and Review of the Literature
スポンサーリンク
概要
- 論文の詳細を見る
Plasma cell leukemia (PCL) is an aggressive variant of multiple myeloma characterized by a high level of plasma cells circulating in the peripheral blood. The prognosis of PCL patients treated with conventional chemotherapy remains poor. Some reports have suggested that both bortezomib and lenalidomide are effective in treating PCL. We herein report a case of primary PCL in which the patient achieved stringent complete remission after receiving combination chemotherapy with reduced-dose bortezomib, lenalidomide and dexamethasone (VRd). This regimen was very effective, and no severe adverse events were observed. A reduced-dose VRd regimen can be considered in PCL patients.
- 社団法人 日本内科学会の論文
著者
-
Inui Yoshiaki
Department Of Gastroenterology And Hepatology Osaka University Graduate School Of Medicine
-
Matsuura Noriko
Department Of Behavioral Sciences Faculty Of Integrated Arts And Sciences Hiroshima University
-
Kawata Sumio
Department Of Biochemistry And Second Department Of Internal Medicine Osaka University Medical Schoo
-
Matsunaga Hitomi
Department Of Hematology And Oncology Graduate School Of Medicine Osaka University
-
Kanakura Yuzuru
Department Of Hematology And Oncology Graduate School Of Medicine
-
Maeda Tetsuo
Department Of General Medicine Kanazawa University Hospital
-
Kataoka Seiko
Department Of Internal Medicine Hyogo Prefectural Nishinomiya Hospital
-
UEDA Shuji
Department of Agriculture, Forestry and Fisheries, Fukuoka Prefectural Government, Fukuoka 812-8577, Japan
-
Matsunaga Hitomi
Department of Internal Medicine, Hyogo Prefectural Nishinomiya Hospital, Japan
-
Kubo Masahiko
Department of Internal Medicine, Hyogo Prefectural Nishinomiya Hospital, Japan
関連論文
- Promoter hypermethylation of DAP-kinase is associated with poor survival in primary biliary tract carcinoma patients
- Common null variant, Arg192Stop, in a G-protein coupled receptor, olfactory receptor 1B1, associated with decreased serum cholinesterase activity
- Factors correlated with plasma renin activity in general Japanese population
- Relationship between antinuclear antibody and microalbuminuria in the general population : the Takahata study
- Early decline of hemoglobin can predict progression of hemolytic anemia during pegylated interferon and ribavirin combination therapy in patients with chronic hepatitis C
- Changes in serum hepatic fibrosis markers in biochemical responders to interferon therapy for chronic hepatitis C
- Identification of missense mutation (G365R) of the Butyrylcholinesterase (BChE) gene in a Japanese patient with familial cholinesterasemia
- Spreading of methylation within RUNX3 CpG island in gastric cancer
- Hypermethylation of the TSLC1 Gene Promoter in Primary Gastric Cancers and Gastric Cancer Cell Lines
- Association of CC chemokine ligand 5 genotype with urinary albumin excretion in the non-diabetic Japanese general population : the Takahata study
- FEV6 and FEV1/FEV6 in Japanese Participants of the Community-Based Annual Health Check: The Takahata Study
- Circulating Levels of Heart-Type Fatty Acid-Binding Protein in a General Japanese Population : Effects of Age, Gender and Physiologic Characteristics
- Clinical utility of trace proteinuria for microalbuminuria screening in the general population
- Genetic Association between Aldehyde Dehydrogenase 2 (ALDH2) Variation and High-Density Lipoprotein Cholesterol (HDL-C) Among Non-Drinkers in Two Large Population Samples in Japan
- Association of an intronic haplotype of the LIPC gene with hyperalphalipoproteinemia in two independent populations
- A Case of Fallopian Tube Carcinoma: Successful Preoperative Diagnosis eith MR Imaging
- Expression of vascular permeability factor (VPF/VEGF) messenger RNA by plasma cells : Possible involvement in the development of edema in chronic inflammation
- HETEROTOPIC GASTRIC MUCOSA IN MECKEL'S DIVERTICULUM INCIDENTALLY FOUND BY DOUBLE BALLOON ENTEROSCOPY
- Down-regulation of hepatic stearoyl-CoA desaturase 1 expression by angiotensin II receptor blocker in the obese fa/fa Zucker rat : possible role in amelioration of insulin resistance and hepatic steatosis
- Separate analysis of asialoglycoprotein receptors in the right and left hepatic lobes using ^Tc-GSA SPECT in patients with acute hepatic damage
- Characteristics of rat bone marrow cells differentiated into a liver cell lineage and dynamics of the transplanted cells in the injured liver
- Successful percutaneous radiofrequency ablation of adrenal metastasis from hepatocellular carcinoma
- Reduction of serum ghrelin concentration during interferon-α therapy in patients with chronic hepatitis C
- Expression of Notch signalling markers in bone marrow cells that differentiate into a liver cell lineage in a rat transplant model
- The Protective Role of Glutathione Peroxidase in Ppoptosis Induced by Reactive Oxygen Species^1
- Localized Relapse in Bone Marrow in a Posttransplantation Patient with t(6 ; 9) Acute Myeloid Leukemia
- Early Onset of Hemophagocytic Syndrome Following Allogeneic Bone Marrow Transplantation
- Expression of CD27 on Peripheral CD4^+ T-Lymphocytes Correlates with the Development of Severe Acute Graft-versus-Host Disease after Allogeneic Bone Marrow Transplantation
- Pharmaceutical Studies for Gene Therapy : Expression of Human Cu, Zn-Superoxide Dismutase Gene Transfected by Lipofection in Rat Skin Fibroblasts
- Role of carbon-11 choline PET/CT in the management of uterine carcinoma : initial experience
- Malignant endocrine tumor of the pancreas associated with von Recklinghausen's disease
- Renal mass formation after bacillus Calmette-Guerin perfusion therapy for carcinoma in situ of the upper urinary tract
- Relationship between Habit of Cigarette Smoking and Airflow Limitation in Healthy Japanese Individuals: The Takahata Study
- Blastic Transformation of Splenic Lymphoma With Villous Lymphocytes After a Well-Controlled Chronic Phase of More Than 10 Years
- Standardized uptake value on FDG-PET as a marker for disease activity in patients with non-Hodgkin's lymphoma : comparison with serum soluble interleukin-2 receptor values
- ^F-FDG-PET in patients with malignant lymphoma having long-term follow-up : staging and restaging, and evaluation of treatment response and recurrence
- High variability of albuminuria in nondiabetic population : the Takahata Study
- Treatment of Primary Intraocular Lymphoma with Intravitreal Methotrexate
- Expression of the RNA-binding protein Musashi1 in adult liver stem-like cells
- Post-transplant lymphoproliferative disorder following renal transplantation : A single-center experience over 40 years
- Constitutively Activated Rho Gunosine Triphosphatases Regulate the Growth and Morphology of Hairy Cell Leukemia Cells
- Constitutive Activation of c-kit by the Juxtamembrane but Not the Catalytic Domain Mutations Is Inhibited Selectively by Tyrosine Kinase Inhibitors STI571 and AG1296
- Comparison of sleep/wake habits of university students with or without a habit of self-awakening
- Roles for deregulated receptor tyrosine kinases and their downstream signaling molecules in hematologic malignancies
- KIT MUTATIONS IN HEMATOPOIETIC MALIGNANCIES
- Molecular Control of Megakaryopoiesis and Thrombopoiesis
- EFFECTS OF ENALAPRIL ON LEFT VENTRICULAR FUNCTION AND MASS IN PATIENTS WITH ESSENTIAL HYPERTENTION
- Statin Therapy Can Prevent In-Stent Restenosis (ISR) after Coronary Stenting in the Patient with Acute Coronary Syndrome (ACS)
- STUDIES ON THE SOMATIC AND MENTAL DEVELOPMENT IN EXPERIMENTALLY INDUCED SFD RAT AFTER BIRTH
- MECHANISM OF RETARDED MENTAL DEVELOPMENT IN MSP-INDUCED SFD RATS, ESPECIALLY ON DNA SYNTHETIC RATE OF THE BRAIN
- Increased Homeostasis Model Assessment-Insulin Resistance Is a Risk Factor for Colorectal Adenoma in Japanese Males
- The Association between Microalbuminuria and Metabolic Syndrome in the General Population in Japan: The Takahata Study
- Performance Assessment of Phased-Array Coil in Breast MR Imaging
- The association between renal tubular damage and rapid renal deterioration in the Japanese population : the Takahata study
- Plasmablastic Extramedullary Plasmacytoma Associated with Epstein-Barr Virus Arising in an Immunocompetent Patient with Multiple Myeloma
- Pulmonary Arterial Hypertension Associated with Chronic Active Epstein-Barr Virus Infection
- ^Tc-GSA SPECT analysis was clinically useful to evaluate the effect of interferon in a patient with interferon non-responsive chronic hepatitis C
- Impact of Cigarette Smoking on Maximal Expiratory Flows in a General Population: the Takahata Study
- Preoperative nodal staging of uterine cancer : is contrast-enhanced PET/CT more accurate than non-enhanced PET/CT or enhanced CT alone?
- Influence of Physician Specialty on Treatment Goals for Diabetic Patients : Results of a Survey given to the Members of the Ishikawa Medical Association
- Safety and efficacy of the terminal complement inhibitor eculizumab in Japanese patients with paroxysmal nocturnal hemoglobinuria : the AEGIS Clinical Trial
- Molecular analysis of a patient with type I Glanzmann thrombasthenia and clinical impact of the presence of anti-αIIbβ3 alloantibodies
- Diffusion-weighted Imaging of a Malignant Brenner Tumor
- The novel and independent association between single-point SNP of NPHP4 gene and renal function in non-diabetic Japanese population : the Takahata study
- Renal biopsy is a helpful tool for the diagnosis of POEMS syndrome
- Development of a Single Bovine Embryo Improved by Co-culture with Trophoblastic Vesicles in Vitamin-supplemented Medium
- Sequence heterogeneity of NS5A and core proteins of hepatitis C virus and virological responses to pegylated-interferon/ribavirin combination therapy
- Recent topics related to nephrogenic systemic fibrosis associated with gadolinium-based contrast agents
- Comparison of Capability of Abdominal 320-Detector Row CT and of 16-Detector Row CT for Small Vasculature Assessment
- Stringent Complete Remission of Primary Plasma Cell Leukemia with Reduced-dose Bortezomib, Lenalidomide and Dexamethasone: A Case Report and Review of the Literature
- Susceptibility-weighted Imaging Effectively Reveals Small Cavernomas
- Successful anticoagulant therapy for two pregnant PNH patients, and prospects for the eculizumab era
- Recent issues in contrast-induced nephropathy