FEV6 and FEV1/FEV6 in Japanese Participants of the Community-Based Annual Health Check: The Takahata Study
スポンサーリンク
概要
- 論文の詳細を見る
Background Forced expiratory volume in 6 seconds (FEV6) is becoming a substitute of forced vital capacity (FVC). However, the Japanese predictive equation for FEV6 has not been established, and the validity for the use of FEV1/FEV6 for diagnosing airflow limitation in Japanese has not been confirmed. Methods Subjects aged 40 or older, who had participated in a community-based health check in Takahata, Japan, from 2004 through 2005, were enrolled. The smoking histories of these subjects were investigated using a self-reporting questionnaire. FVC, FEV1, and FEV6 were measured using spirometric machines. Predictive equations of FEV6 were obtained from never-smoking subjects without history of pulmonary diseases by multiple linear regression assay. Results FEV6 and FEV1/FEV6 were significantly correlated with FVC (r=0.998, p<0.001) and FEV1/FVC (r=0.989, p<0.001), respectively. The cutoff values of percent predicted (%) FEV6 and FEV1/FEV6 for discrimination of having the restrictive lung disorder determined by %FVC <0.8 and having the airflow limitation determined by FEV1/FVC <0.7 were 0.80 and 0.72, respectively (%FEV6: sensitivity=0.995, specificity=0.983, positive predictive value <PPV>=0.832, negative predictive value <NPV>=1.000; FEV1/FEV6: sensitivity=0.942; specificity=0.971; PPV=0.787; NPV=0.993). When the 5th percentile the lower limit of normal values was used as criterion for discrimination of having airflow limitation, sensitivity, specificity, PPV, and NPV of FEV1/FEV6 were 0.932, 0.985, 0.808, and 0.995, respectively. Conclusion The results of the present study suggest that %FEV6 and FEV1/FEV6 are excellent substitutes for %FVC and FEV1/FVC, respectively. We confirmed the validity of the use of FEV6 and FEV1/FEV6 for identifying pulmonary diseases in Japanese individuals.
著者
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KAWATA Sumio
Department of Gastroenterology, Yamagata University School of Medicine
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KUBOTA Isao
Department of Cardiology, Pulmonology and Nephrology, Yamagata University of School of Medicine
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KATO Takeo
Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University
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SHIBATA Yoko
Department of Cardiology, Pulmonology and Nephrology, Yamagata University School of Medicine
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Watanabe Tetsu
Department of Cardiology, Pulmonology, and Nephrology
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Inoue Sumito
Department of Internal Medicine, Yamagata Prefectural Shinjo Hospital
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KONTA Tsuneo
Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine
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SATO Michiko
Department of Forest and Forest Products Science, Faculty of Agriculture, Kyushu University
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IGARASHI AKIRA
Department of Surgery II, Hamamatsu University School of Medicine
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KIMURA Tomomi
Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental Universit
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Kishi Hiroyuki
Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Japan
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Osaka Daisuke
Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Japan
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Abe Shuichi
Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Japan
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Tokairin Yoshikane
Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Japan
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Yamauchi Keiko
Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Japan
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Aida Yasuko
Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Japan
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Shibata Yoko
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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Kimura Tomomi
Department Of Biochemistry Showa University School Of Medicine
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Kawata Sumio
Department Of Biochemistry And Second Department Of Internal Medicine Osaka University Medical Schoo
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Konta Tsuneo
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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Igarashi Akira
Department Of Applied Chemistry Faculty Of Engineering Kogakuin University
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Kubota Isao
Department Of Cardiology Pulmonology And Nephrology Yamagata University Of School Of Medicine
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Watanabe Tetsu
Department Of Basic Clinical Science And Public Health Tokai University School Of Medicine
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Sato Michiko
Department Of Biotechnology Tokyo University Of Agriculture And Technology
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KATO Takeo
Department of Applied Physics, Osaka City University
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Sato Michiko
Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Japan
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Watanabe Tetsu
Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Japan
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Abe Shuichi
Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine
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Osaka Daisuke
Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine
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Inoue Sumito
Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine
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Kishi Hiroyuki
Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine
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