THE DISTRIBUTION AND POSSIBLE SIGNIFICANCE OF NATURAL KILLER CELLS (HNK-1^+ CELL) IN THE HUMAN SPLEEN
スポンサーリンク
概要
- 論文の詳細を見る
The distribution of natural killer cells in human spleen was studied immunohistochemically and immuno-electron microscopically using a monoclonal antibody for human natural killer cell (HNK-1). The reactivity of this antibody to the formalin fixed and paraffin embedded specimens was confirmed and technical improvement was attempted. HNK-1^+ cells were divided into two groups according to their distribution and cytological characteristics. One group consisted of cells distributed around the white pulp and in the red pulp and the other group localized in the germinal center (GC). The former morphologically resembled large granular lymphocyte (LGL) of peripheral blood and was thought to be the LGL of the blood circulating in the spleen. Although the latter consisted of lymphocytes having electron dense granules as LGL, their size and the ratio of nucleus to cytoplasm were greater than those of the former and their ultrastructural appearance indicated promoted secretory activity. The number of HNK-1^+ cells in GC was intimately related to the development of GC. Furthermore, their population correlated with the number of mitoses of centroblasts, tingible body macrophages or peanut lectin-bound immature B lymphocytes, respectively. Based on these facts, a possibility was suggested that HNK-1^+ cells in GC might be in an active phase and they might be related to the physiological regulation of differentiation and expansion of B cell. Phenotypic expression of HNK-1^+ cells was examined by double immunoenzymatic labelling, but no differences were found between the HNK-1^+ cells in GC and in the red pulp.
- 日本組織細胞化学会の論文
著者
-
ISHIKAWA Eisei
Department of Mitsui Memorial Laboratory, The Jikei University School of Medicine
-
Takasaki Satoshi
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
-
Tanaka Hisako
Division Of Morphology Bio-medical Research Laboratories
-
Tanaka Hisako
Division Of Morphology Bio Medical Research Laboratories The Jikei University School Of Medicine
-
Suzuki Teruo
Division Of Morphology Bio-medical Research Laboratories
-
MUROYA TETSUYA
Department of Pathology, Jikei University School of Medicine
-
Muroya Tetsuya
Department Of Pathology Jikei University School Of Medicine
-
Takasaki Satoshi
Department Of Pathology Jikei University School Of Medicine
-
Takasaki Satoshi
Department Of Cardiology Pulmonology And Nephrology ; Course Of Internal Medicine And Molecular Ther
-
Suzuki Teruo
Division Of Morphology Bio Medical Research Laboratories The Jikei University School Of Medicine
-
Tanaka Hisako
Division Of Molecular Cell Biology
-
MUROYA Tetsuya
Department of Gynecology, Center for Healthcare and Public Concern, Tokyo Kenbikyoin Foundation Genki Plaza
関連論文
- Endovascular Papillary Angioendothelioma (Dabska Tumour) : Like Tumour Associated with Lymphoedema
- Solitary fibrous tumor of the nasal cavity and orbit
- Common null variant, Arg192Stop, in a G-protein coupled receptor, olfactory receptor 1B1, associated with decreased serum cholinesterase activity
- Persistently Increased Serum Concentration of Heart-Type Fatty Acid-Binding Protein Predicts Adverse Clinical Outcomes in Patients With Chronic Heart Failure
- Serum Carboxy-Terminal Telopeptide of Type I Collagen (ICTP) Predicts Cardiac Events in Chronic Heart Failure Patients With Preserved Left Ventricular Systolic Function
- PJ-174 Heart-Type Fatty Acid Binding Protein can Predict Left Ventricular Remodeling in Patients with Acute Myocardial Infarction(Acute myocardial infarction, clinical (diagnosis/treatment)-9, The 71st Annual Scientific Meeting of the Japanese Circulation
- Combination of conventional biomarkers for risk stratification in chronic heart failure
- Factors correlated with plasma renin activity in general Japanese population
- PJ-779 8-Hydroxy-2'-Deoxyguanosine Predicts Adverse Clinical Outcomes in Patients with Heart Failure(PJ131,Heart Failure (Laboratory/Biomarkers) 2 (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-645 Risk Stratification by Combination of Serum Neopterin and TNF α in Patients with Heart Failure(PJ108,Heart Failure (Laboratory/Biomarkers) 1 (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Risk Stratification of Chronic Heart Failure Patients by Multiple Biomarkers : Implications of BNP, H-FABP, and PTX3
- Relationship between antinuclear antibody and microalbuminuria in the general population : the Takahata study
- PJ-585 Heart-type Fatty Acid-binding Protein Levels Predict the Occurrence of Appropriate Implantable Cardioverter Defibrillator Therapy for Ventricular Tachycardia/Fibrillation(Arrhythmia, diagnosis/Pathophysiology/EPS(10)(A),Poster Session(Japanese),The
- PJ-524 Atrial Endothelial Impairment Induced by Innate Immune may cause Atrial Thrombosis(Infection/Inflammation/Immunity(03)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-309 Diacylglycerol Kinase-ζ Rescues G α q-induced heart failure in transgenic mice(Heart failure, basic(06)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-130 Multiple Biomarkers for the Prediction of Cardiac Events in Chronic Heart Failure (CHF) Patients(Heart failure, clinical(14)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-065 High Serum Level of Neopterin is a Risk Factor of Patients with Heart Failure(Heart failure, clinical(01)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-187 Pentraxin 3, a New Marker for Vascular Inflammation, is Increased in Patients with Unstable Angina Pectoris(Angina pectoris, basic/clinical-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Diminution of angiotensin II-induced contraction of the abdominal aorta isolated from Watanabe heritable hyperlipidemic rabbits
- Chronic Hypertriglyceridemia In Watanabe Heritable Hyperlipidemic Rabbits (a model for familial combined hyperlipidaemia) Accerelates Endothelial and Medial Smooth Muscle Dysfunctions
- Association of CC chemokine ligand 5 genotype with urinary albumin excretion in the non-diabetic Japanese general population : the Takahata study
- Spindle cell hemangioendothelioma : An immunohistochemical and flow cytometric study of six cases
- PJ-492 Cardiac 123I-MIBG Imaging can Classify Diastolic Heart Failure Patients(PJ083,Nuclear Cardiology (Coronary, Myocardium) 3 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-218 Dynamic Technetium-99m-Sestamibi SPECT Predicts Cardiac Function in Chronic Phase in Patients with Acute Myocardial Infarction (AMI)(PJ037,Nuclear Cardiology (Coronary, Myocardium) 1 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting
- PJ-104 Serum Midkine Predicts Cardiac Events in Chronic Heart Failure Patients(Growth factor/Cytokine(02)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-051 Diacylglycerol Kinase-ε Restores Cardiac Dysfunction under Chronic Pressure Overload : A New Specific Regulator of G α q Signaling Cascade(Cardiac hypertrophy, basic/clinical(02)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the
- PE-540 Pentraxin 3 (PTX3) Predicts Adverse Clinical Outcomes in Heart Failure Patients with Preserved Left Ventricular Systolic Function (LVSF)(Heart failure, clinical(12)(M),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circu
- OJ-139 Multiple Biomarkers Approach for Risk Stratification in Heart Failure Patients(Heart failure, clinical(05)(M),Oral Presentation (Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-266 Diacylglycerol Kinase α Exacerbates Cardiac Injury after Ischemia/reperfusion in Transgenic Mouse Hearts(Acute myocardial infarction, basic(01)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- FRS-062 Soluble Receptor for Advanced Glycation End Products is a Prognostic Factor for Heart Failure(Prognostic Biomarkers of Heart Failure(M),Featured Research Session,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Clinical utility of trace proteinuria for microalbuminuria screening in the general population
- The novel and independent association between single-point SNP of NPHP4 gene and renal function in non-diabetic Japanese population: the Takahata study
- An angiotensin II type-I receptor blocker, olmesartan medoxomil, attenuates lipid peroxidation in renal injury induced by subtotal nephrectomy
- Collective Mode of Spin-Density-Wave in (TMTSF)_2ClO_4 : Condensed Matter: Electronic Properties, etc.
- Depinning of Spin-Density-Wave in (TMTSF)_2ClO_4 : Condensed Matter: Electronic Properties, etc.
- THE DISTRIBUTION AND POSSIBLE SIGNIFICANCE OF NATURAL KILLER CELLS (HNK-1^+ CELL) IN THE HUMAN SPLEEN
- 218. The Influence of Cephacetrile on the Lysosomes of Proximal Convoluted Tubular Epithelium (The Second Meeting for the Study of Toxic Effect)
- Initial Changes of Hepatic Glycogen Granules and Glycogen Phosphorylase a After Exposure to 7,12-dimethylbenz[a]anthracene in Rats
- Magnetic Oscillation of Thermoelectric Power in the Organic Superconductorκ-(BEDT-TTF)_2 Cu(NCS)_2
- A New Organic Metal Based on the DHTTF (Dihydrotetrathiafulvalene) Derivative, (MDHT)_2AuI_2
- FRS-102 Serum Soluble Receptor for Advanced Glycation End Product Level is Decreased in Acute Coronary Syndrome(Biomarker of Cardiovascular Disease, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- FRS-033 Pentraxin 3, a New Marker for Vascular Inflammation, Predicts Adverse Clinical Outcomes in Patients with Heart Failure(Pathophysiology of Cardiovascular Disease, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- LAP-1 Cold Preservation Solution for Isolation of High-Quality Human Pancreatic Islets
- A PRELIMINARY EXPERIMENT OF REPEATED ALCOHOL ADMINISTRATION IN RHESUSMONKEYS (The Fourth Meeting for the Study of Toxic Effect)
- High variability of albuminuria in nondiabetic population : the Takahata Study
- Phenotypic Characteristics and Significance of Reticular Meshwork Surrounding Splenic White Pulp of Mice
- Detection of albumin mRNA of albumin positive hepatocytes in analbuminemic rat by in situ hybridization
- DRUG INDUCED ALTERATION IN THE RENAL PROXIMAL CONVOLUTED TUBULUS OF RATS (The Fourth Meeting for the Study of Toxic Effect)
- Autoimmune forms of chronic hepatitis associated with hepatitis C virus (HCV) infection with and without HCV-RNA : Histological differences from pure autoimmune hepatitis and chronic hepatitis C
- Changes in Lipoprotein Profile after Selective LDL Apheresis
- The Association between Microalbuminuria and Metabolic Syndrome in the General Population in Japan: The Takahata Study
- IN SITU CONFIGURATIONS OF MITOCHONDRIA IN INHIBITED AND ACCELERATED RESPIRATORY CONDITIONS OF ISOLATED RAT HEPATOCYTES AS OBSERVED BY CHEMICAL AND PHYSICAL FIXATIONS
- The association between renal tubular damage and rapid renal deterioration in the Japanese population : the Takahata study
- The novel and independent association between single-point SNP of NPHP4 gene and renal function in non-diabetic Japanese population : the Takahata study
- Gene expression profiles and microsatellite instability in uterine corpus endometrioid adenocarcinoma