Subclinical Declines in the Verbal Fluency and Motor Regulation of Patients with AVIM (Asymptomatic Ventriculomegaly with Features of Idiopathic NPH on MRI): A Case-controlled Study
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概要
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Objective We previously reported that, on brain MRI, iNPH features were observed in approximately 1% of asymptomatic elderly community dwellers. This phenomenon is designated asymptomatic ventriculomegaly with features of iNPH on MRI (AVIM). The aim of the present study was to clarify whether a subclinical decline in the neuropsychological function is present in patients with AVIM. Methods We examined eight subjects with AVIM, six subjects with possible iNPH and 21 elderly controls. Neuropsychological tests were used, including the mini-mental state examination (MMSE), the Hasegawa dementia scale-revised (HDS-R), the frontal assessment battery (FAB), the trail making test A&B and semantic and letter verbal fluency tests. Results When comparing the individuals with AVIM with the control subjects, significant differences were found in the scores achieved on the semantic verbal fluency tests and Luria's motor series (fist-edge-palm), a subtest of the FAB. Conclusion The present study suggests that individuals with AVIM demonstrate a slight subclinical decline in the cognitive function and motor regulation, which may represent a prodromal stage of iNPH.
著者
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Takahashi Yoshimi
Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University
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Wada Manabu
Department Of Neurology Hematology Metabolism Endocrinology And Diabetes Yamagata University School
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Kawanami Toru
Department Of Neurology Hematology Metabolism Endocrinology And Diabetes Yamagata University School
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Iseki Chifumi
Department Of Neurology Hematology Metabolism Endocrinology And Diabetology Yamagata University Faculty Of Medicine
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KATO Takeo
Department of Applied Physics, Osaka City University
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