Steroid-responsive Thalamic Lesions Accompanying Microbleeds in a Case of Hashimoto's Encephalopathy with Autoantibodies Against α-enolase

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概要

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• A 67-year-old man receiving antithrombotic therapy developed rapidly progressive amnesia. T2-weighted images of brain MRI revealed hyperintense lesions in the bilateral thalami accompanied by microbleeds. Antithyroglobulin antibodies and autoantibodies against the N-terminal of α-enolase (NAE) were identified in the patient's serum; therefore, Hashimoto's encephalopathy (HE) was suspected. Although the patient's radiological findings improved following steroid therapy, his symptoms did not improve, possibly due to increased thalamic microbleeds. Because anti-NAE antibodies are possibly associated with vasculitis, HE accompanied by anti-NAE antibodies may be exacerbated by microbleeds in patients receiving antithrombotic therapy.

• 社団法人 日本内科学会の論文

著者

• Tanji Haruko

  Department Of Geriatric And Respiratory Medicine Center For Asian Traditional Medicine Research Toho

• Yamaguchi Yoshitaka

  Department Of Advanced Materials Chemistry Graduate School Of Engineering Yokohama National Universi

• Wada Manabu

  Department Of Neurology Hematology Metabolism Endocrinology And Diabetes Yamagata University School

• Yoneda Makoto

  Second Department Of Internal Medicine (neurology) Faculty Of Medical Sciences University Of Fukui

• Kawanami Toru

  Department Of Neurology Hematology Metabolism Endocrinology And Diabetes Yamagata University School

• Kurokawa Katsuro

  Department Of Neurology Hematology Metabolism Endocrinology And Diabetology Yamagata University Faculty Of Medicine

• KATO Takeo

  Department of Applied Physics, Osaka City University

• Tanji Haruko

  Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of Medicine, Japan

• Tanji Kazuyo

  Department of Clinical Neuroscience, Yamagata University Graduate School of Medical Science, Japan

• Yoneda Makoto

  Second Department of Internal Medicine (Neurology), Faculty of Medicine, University of Fukui, Japan

• Yamaguchi Yoshitaka

  Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of Medicine, Japan

• Kurokawa Katsuro

  Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of Medicine, Japan

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