Cyclosporine Level in Blood as Monitored by Area-under-the-Curve (AUC). (Second Report). Comparison between AUC Monitoring and Trough Level Monitoring.:Comparison between AUC Monitoring and Trough Level Monitoring

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Recent studies have suggested that the measurement of the areaunderthe-curve (AUC) is a more effective method of controlling cyclosporine (CYA) therapy . This paper has investi gated the use of AUC monitoring compared with trough level monitoring.<BR>CYA (dose: 1.6-8.3mg/kg/day) was administereted orally to 28 renal transplant patients (10-52 years old). Blood specimens were collected at trough level, 1, 2, 3, 6, 8 and 12 hr or trough level, 1, 3 and 6 hr to determine the whole blood concentration of CYA . The AUC was calculated by the trapezoidal method or multiple linearregression method.<BR>The correlation coefficient of AUC and the trough level with the administereted oral dose, expressed as mg/kg/day by the polynomial method, were 0.435 and 0. 380, respectively. The correlation coefficient between the trough level and AUC was 0 .646. The mean AUC of the initial stage and maintenance stage were 4661.8 ng·hr/ml and 2721.1-3072 .7 ng·hr/ml, respectively. In 9 paired observations, the coefficient of variation (CV %) in AUC was significantly smaller than that of trough level (p< 0. 05). The serum potassium (K) with an AUC of 5000-6000 ng·hr/ml was significantly higher than K with an AUC of 2000-3000 ng·hr/ml (p<O. 05).<BR>These results suggest that AUC monitoring is very useful for precise detection of the dosage ajustment in clinical practice.
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