排卵後のEstrogen投与とその避妊機序について

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Postovulatory estrogen treatment has been shown to be an effective method for contraception in both women and monkeys. Recently postovulatory plasma LH peak has been observed in the normal menstrual cycle of the baboon. This study was designed to obtain information on the relationship between postovulatory LH and luteolysis. Blood samples and vaginal smears were obtained at 0800 hr daily in both control and treatment cycles of four adult female baboons. Plasma levels of estradiol, progesterone and LH were determined. In the treatment cycle, 300 μg of estradiol benzoate (EB) (Progynon, Schering) was given sc twice daily at 0800 and 1600 hr beginning the day after the expected day of ovulation and continuing for 5 days. Plasma levels of estradiol were maintained over 500 pg/ ml during the EB treatment period which exceeded the control preovulatory plasma estradiol peak (300-420 pg/ml) by about 400-600 pg/ml. The length of the luteal phase during the treatment cycle was shortened in one of the four baboons. In the control cycle both a preovulatory LH peak and a postovulatory (1-3 days following ovulation) LH peak were observed. In three of the four baboons, there was both an increase in the plasma LH concentrations and a premature decline in plasma progesterone concentrations during the EB treated luteal phase as compared to those during the control luteal phase. In one baboon, no change was observed in the plasma LH and progesterone levels as compated to the control levels. These findings suggest that estrogen in large doses during the postovulatory period may induce functional luteolysis, i.e. suppression of the steroidogenesis in the corpus luteum and that insufficient progesterone secretion may make the endometrium unprepared for implantation. Massive LH release by postovulatory estrogen treatment suggests that hypothalamic-hypophyseal axis may participate in the mechanism of this luteolytic effect in the baboon.
日本内分泌学会の論文

排卵後のEstrogen投与とその避妊機序について

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