“もやもや”病の外科治療前後のRI image 変化について

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Cerebral hemodynamic studies were made in 36 child cases of “Moyamoya” disease, using Technetium-99m and a Gamma scintillation camera. About 10mCi 99mTc was injected into the anterior cubital vein as a bouls, and serial brain scintigrams in one second interval were obtained with Gamma scintillation camera (Ohio-nuclear Σ410t) and processed on an on-line radioisotope processing system including microcomputer (DEC PDP 11/34, 11/60 GAMMA 11). Results were as follows. 1. Study of serial brain scintigraphy The characteristic images were obtained in preoperative cases: early accumulation of radioisotope-activities in the base of the skull, corresponding to the basal “Moyamoya” vessels, and the poor filling in the area of anterior and middle cerebral artery, indicating disturbance of the cerebral circulation. After surgery, early accumulation of RI activities in the base of the skull were decreased and the evidence of improved cerebral circulation in the territories of the MCA was obtained, but poor filling in the territories. of the ACA persisted. 2. Measurement of local mode of transit time (MOTT) Quantitative analyses were made by our modified method which was orginally reported by Ordendorf. i) Regions of interest (ROI) were settled in the area of basal “Moyamoya” vessels and in the territories. of MCA on the image of A-P view. The mean values of MOTT in the MCA territories was significantly longer than that in the basal “Moyamoya” in preoperative cases (10.2±2.8, 7.6±2.5sec., n=28, respectively). After surgery, shortening of MOTT in the MCA territory was observed (7.2±1.7sec.,n=22). ii) ROI were also settled in the area of basal “Moyamoya”, frontal part, parietal part and occipital part on the image of lateral view. The mean values of MOTT in the area of basal “Moyamoya” was significantly different from those in the areas of parietal and occipital parts in preoperative cases (7.1 ± 1.8, 10.2±3.0, and 10.0±3.8 sec., n=15, respectively) After surgery, shortening of MOTT in the areas of parietal and occipital parts was also observed (6.8±1.4, 6.8±1.5 sec., n= 12, respectively).

“もやもや”病の外科治療前後のRI image 変化について

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