虚血性脳血管障害の術前・術後のCBF study

概要

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Pathophysiological study was made about the effect of ST-MC bypass surgery in the cases of“Moya-moya”disease and in the cases of ICA and/or MCA occlusion. Cerebral blood flow (CBF) was measured by use of Argon and medical masspectrometry (MEDSPECT II). CBF values were calculated according to Fick's principle. Cerebral oxygen consumption was calculated by arterial-jugular oxygen content difference and CBF.<BR>In eleven cases of“Moyamoya”disease, marked decrease of cortical blood flow was characteristic. After bypass surgery increase of CBF was noted accompanied by increase of cerebral oxygen consumption.<BR>In the cases with ICA and/or MCA occlusion, increase of CBF and cerebral oxygen consumption were also observed after ST-MC bypass surgery.<BR>In the other three cases with ICA and/or MCA occlusion, the relation among CBF, mean arterial pressure and electroencephalogram was studied during drip infusion of trimethaphan. In all three cases, the widening of the range of autoregulation were noted after ST-MC bypass surgery.<BR>From these evidences it was verified that ST-MC bypass surgery is effective to not only inprovement of CBF and cerebral metabolism, but also augumentation of cerebral circulatory reserve.