Polycationic Gramicidin S Analogues with Both High Antibiotic Activity and Very Low Hemolytic Activity
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概要
- 論文の詳細を見る
The substitution of each constituent amino acid residue of gramicidin S (GS), cyclo(-Val1,1′-Orn2,2′-Leu3,3′-D-Phe4,4′-Pro5,5′-)2 with Lys residue indicated that each side chain structure of the constituent amino acid residues affect largely the antibiotic activity and hemolytic activity of GS. Further, the substitution of D-Phe4,4′ and Pro5,5′ residues with basic amino acid residues as a Lys residue results the high antibiotic activity and the very low hemolytic activity. Thus, we have found novel positions on the scaffold of GS at D-Phe4,4′ and Pro5,5′ residues whose modification will significantly increase the therapeutic index.
- 公益社団法人 日本薬学会の論文
著者
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Shindo Mitsuno
Department Of Food Science And Nutrition Osaka Shoin Women's University
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Uchida Yoshiki
Department Of Applied Chemistry Faculty Of Engineering Osaka City University
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Harada Takuji
Department Of Chemical Engineering Graduate School Of Engineering Tohoku University
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Tamaki Makoto
Department Of Chemistry And Biomolecular Science Toho University
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Fujinuma Kenta
Department Of Chemistry Toho University
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Takanashi Kazumasa
Department Of Chemistry Toho University
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Kimura Masahiro
Department Of Chemistry Graduate School Of Science Tokyo Metropolitan University
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Uchida Yoshiki
Department of Health and Nutrition, Osaka Shoin Women's University
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