Possible interpretation of inactivity of novel gramicidin S analogs by CD spectral analysis of tetrapeptide derivatives related to the analogs.
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概要
- 論文の詳細を見る
CD spectral analysis of chromophoric derivatives of tetrapeptides related to the β-turn part of [D-Val<SUP>1,1′</SUP>]-and [D-Val<SUP>1,1′</SUP>, L-Phe<SUP>4,4′</SUP>]-gramicidin S indicated that they had very low preference for β-turn formation. The results suggested that neither analog could take gramicidin S-like β-sheet conformation. It seems noteworthy that the side-chain bulkiness of the 4th amino acid of a tetrapeptide affects the stability of β-turn.
- 公益社団法人 日本化学会の論文
著者
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Tamaki Makoto
Department Of Chemistry And Biomolecular Science Toho University
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Sato Kazuki
Mitsubishi Kasei Institute Of Life Sciences
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Nagai Ukon
Mitsubishi-Kasei Institute of Life Sciences
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