Studies on the Secondary Structure of Bradykinin in Aqueous Solution. Syntheses, Circular Dichroism Spectra, and Biological Activities of Bradykinin Analogs Containing 5-Aminovaleric Acid Residue.
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概要
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Eight bradykinin analogs containing 5-aminovaleric acid residue were synthesized by a solution method. Based on the consideration concerning their CD spectra, the presence of an intramolecular 3→1 hydrogen bond between the carbonyl oxygen of Ser<SUP>6</SUP> and the amide proton of Phe<SUP>8</SUP>, an intramolecular 4→1 hydrogen bond between the carbonyl oxygen of Pro<SUP>2</SUP> and the amide proton of Phe<SUP>5</SUP>, and a salt bridge between the guanidino group of Arg<SUP>1</SUP> and the carboxyl group of Arg<SUP>9</SUP>, was proposed for the secondary structure of bradykinin in aqueous solution. The biological activities of these analogs depend on the presence of both Phe residues at positions 5 and 8, and Arg residues at positions 1 and 9. No correlation between the biological activities and the secondary structure could be found.
- 公益社団法人 日本化学会の論文
著者
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Tamaki Makoto
Department Of Chemistry And Biomolecular Science Toho University
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Sofuku Shosuke
Department Of Chemistry College Of Science Rikkyo University
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Muramatsu Ichiro
Department Of Chemistry College Of Science Rikkyo University
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Hashimoto Chikao
Department Of Chemistry Jikei University School Of Medicine
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