Synthesis and properties of gramicidin S analogs containing D-Phe-L-Pro-D-Val or L-Phe-L-Pro-D-Val sequences in place of D-Phe-L-Pro-L-Val sequence in the .BETA.-turn part of the antibiotic.

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概要

• 論文の詳細を見る

• In order to investigate the contribution of configurations of amino acid residues around Pro residues in gramicidin S to its activity and conformation, [D-Val<SUP>1,1′</SUP>]- and [D-Val<SUP>1,1′</SUP> L-Phe<SUP>4,4′</SUP>]-gramicidin S were synthesized by a liquid-phase method. The CD spectra of these analogs and gramicidin S in aqueous solutions differ from each other, indicating that these peptides have different conformations. These analogs have practically no activity against the Gram-positive microorganisms tested, indicating the importance of the presence of the D-Phe–Pro–Val sequence in gramicidin S regarding activity.

• 公益社団法人 日本化学会の論文

著者

• Tamaki Makoto

  Department Of Chemistry And Biomolecular Science Toho University

• Muramatsu Ichiro

  Department Of Chemistry College Of Science Rikkyo University

• Takimoto Michiaki

  Department Of Chemistry Faculty Of Science Toho University

• Sakamoto Honami

  Department of Chemistry, Faculty of Science, Toho University

• Okitsu Tadashige

  Department of Chemistry, Faculty of Science, Toho University

• Araki Mie

  Department of Chemistry, Faculty of Science, Toho University

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