Syntheses of gramicidin S analogs containing .DELTA.-aminovaleric acid. [5-1'-.DELTA.-Aminovaleric acid]-gramicidin S and [5-1', 5'-1-bis(.DELTA.-aminovaleric acid)]-gramicidin S.

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概要

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• Gramicidin S (GS) analogs, [5–1′-(δ-aminovaleric acid]-GS dihydrochloride (XIII) and [5–1′, 5′–1-bis(δ-aminovaleric acid)]-GS dihydrochloride (XIX), were synthesized. Both peptides are the analogs in which one or two L-prolyl-L-valyl residues of GS are replaced with one or two δ-aminovaleric acid residues. The spectra of optical rotatory dispersion (ORD) and circular dichroism (CD) of XIII and XIX were measured. The molar optical rotation of XIII is smaller than that of GS, but its ORD spectrum resembles that of GS. Analog XIII shows some antimicrobial activity, but not the analog XIX.

• 公益社団法人 日本化学会の論文

著者

• YOSHIDA Akio

  Department of Cardiovascular Medicine, Tottori University Faculty of Medicine

• Sofuku Shosuke

  Department Of Chemistry College Of Science Rikkyo University

• Muramatsu Ichiro

  Department Of Chemistry College Of Science Rikkyo University

• Yoshida Akio

  Department of Chemistry, College of Science, Rikkyo (St. Paul's) University

• Baba Hiroki

  Department of Chemistry, College of Science, Rikkyo (St. Paul's) University

• Sofuku Shosuke

  Department of Chemistry, College of Science, Rikkyo (St. Paul's) University

• Baba Hiroki

  Department of Chemistry, College of Science, Rikkyo (St. Paul's) University

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