Syntheses of gramicidin S analogs containing .DELTA.-aminovaleric acid. [5-1'-.DELTA.-Aminovaleric acid]-gramicidin S and [5-1', 5'-1-bis(.DELTA.-aminovaleric acid)]-gramicidin S.
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概要
- 論文の詳細を見る
Gramicidin S (GS) analogs, [5–1′-(δ-aminovaleric acid]-GS dihydrochloride (XIII) and [5–1′, 5′–1-bis(δ-aminovaleric acid)]-GS dihydrochloride (XIX), were synthesized. Both peptides are the analogs in which one or two L-prolyl-L-valyl residues of GS are replaced with one or two δ-aminovaleric acid residues. The spectra of optical rotatory dispersion (ORD) and circular dichroism (CD) of XIII and XIX were measured. The molar optical rotation of XIII is smaller than that of GS, but its ORD spectrum resembles that of GS. Analog XIII shows some antimicrobial activity, but not the analog XIX.
- 公益社団法人 日本化学会の論文
著者
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YOSHIDA Akio
Department of Cardiovascular Medicine, Tottori University Faculty of Medicine
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Sofuku Shosuke
Department Of Chemistry College Of Science Rikkyo University
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Muramatsu Ichiro
Department Of Chemistry College Of Science Rikkyo University
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Yoshida Akio
Department of Chemistry, College of Science, Rikkyo (St. Paul's) University
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Baba Hiroki
Department of Chemistry, College of Science, Rikkyo (St. Paul's) University
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Sofuku Shosuke
Department of Chemistry, College of Science, Rikkyo (St. Paul's) University
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Baba Hiroki
Department of Chemistry, College of Science, Rikkyo (St. Paul's) University
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