Synthesis of Cyclic Oligopeptides Containing an Arg-Gly-Asp (RGD) Sequence

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概要

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• The synthesis of cyclic RGD peptides with 8-10 residues cyclized by an amide bond and the relationship between their structure and activity (i.e. circular dichroism spectrum and inhibition of platelet aggregation) are reported. The linear peptides were synthsized by the solution method and their cyclization was performed in high dilution using DPPA.

• 公益社団法人日本薬学会の論文
• 1999-12-15

著者

• Takada Yoichi

  Department Of Chemistry Rikkyo University

• SOFUKU Shosuke

  Department of Chemistry, College of Science, Rikkyo University

• Satake T

  Department Of Chemistry Rikkyo University

• HOSHIDA Akiko

  Department of Chemistry, Rikkyo University

• SHIMADA Takehiro

  Department of Chemistry, Rikkyo University

• TAKAKUWA Takashi

  JASCO Corporation

• Sofuku S

  Department Of Chemistry Rikkyo University

• Sofuku Shosuke

  Department Of Chemistry College Of Science Rikkyo University

• Hoshida Akiko

  Department Of Chemistry Rikkyo University

• Shimada Takehiro

  Department Of Chemistry College Of Science Rikkyo University

関連論文

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• Synthesis of Cyclic Oligopeptides Containing an Arg-Gly-Asp (RGD) Sequence
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• Synthesis of RGDFPASS-containing Cystine Peptides and Isolation of RGD-recognizing Receptor in Sand Dollar Embryo by the Peptide-Affinity Chromatography
• Structure and Activity of Fibronectin-related Peptides. The Role of Amino Acid Residues of Positions 5 and 6 in RGDSPASS-containing Cyclic Decapeptide(FR-1)
• The dansyl Group as a Molecular Probe for the Histochemical Localization of a Synthetic Fibronectin-related Peptide
• Design and Synthesis of Fibronectin-related Peptides. Ala-analogs of RGDSPASS Containing Cystine Peptide (FR-1)
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• Synthesis of Fibronectin Related Peptides : N^α-Methyl Amino Acid-containing Peptides
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• Navigator-gated Non-contrast Renal MR Angiography : : Qualitative and Quantitative Comparison of 3T and 1.5T Images
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