Synthesis of a Gramicidin S Analog Containing δ-Aminovaleric Acid, [4–5-δ-Aminovaleric Acid]-Gramicidin S
スポンサーリンク
概要
- 論文の詳細を見る
In order to investigate the contribution of amide bond in peptide to its activity and conformation, a new type of analog of gramicidin S, [4–δ-aminovaleric acid]-gramicidin S, was synthesized, in which one of the D-phenyl-alanyl-L-proline residues of gramicidin S was replaced with δ-aminovaleric acid residue. The analog peptide has antimicrobial activity and shows similar ORD and CD spectra to those of gramicidin S. The linear peptide (Val–Orn–Leu–δAva–Val–Orn–Leu–D–Phe–Pro) has no activity and its ORD and CD spectra are nearly the same as those of random coil of polypeptide.
- 公益社団法人 日本化学会の論文
著者
関連論文
- Synthesis of Fibronectin-related Peptides : the RGD Peptides and the Third Domain Peptides
- Synthesis of Cyclic Oligopeptides Containing an Arg-Gly-Asp (RGD) Sequence
- Histological distribution of FR-1, a cyclic RGDS-peptide, binding sites during early embryogenesis, and isolation and initial characterization of FR-1 receptor in the sand dollar embryo
- Synthesis of RGDFPASS-containing Cystine Peptides and Isolation of RGD-recognizing Receptor in Sand Dollar Embryo by the Peptide-Affinity Chromatography
- Structure and Activity of Fibronectin-related Peptides. The Role of Amino Acid Residues of Positions 5 and 6 in RGDSPASS-containing Cyclic Decapeptide(FR-1)
- The dansyl Group as a Molecular Probe for the Histochemical Localization of a Synthetic Fibronectin-related Peptide
- Design and Synthesis of Fibronectin-related Peptides. Ala-analogs of RGDSPASS Containing Cystine Peptide (FR-1)
- Design and Synthesis of Cyclic Fibronectin Related Peptides, RGDSPASS Containing Cystine Peptides
- SYNTHESIS OF FIBRONECTIN-RELATED OLIGOPEPTIDES CONTAINING N-ACETYL-D-GLUCOSAMINE
- Synthesis of Fibronectin Related Peptides : N^α-Methyl Amino Acid-containing Peptides
- Synthesis of RGD Peptides Linked with N-Acetylglucosamine
- An RGDS peptide-binding receptor, FR-1R, localizes to the basal side of the ectoderm and to primary mesenchyme cells in sand dollar embryos
- Syntheses of gramicidin S analogs containing .DELTA.-aminovaleric acid. [5-1'-.DELTA.-Aminovaleric acid]-gramicidin S and [5-1', 5'-1-bis(.DELTA.-aminovaleric acid)]-gramicidin S.
- Synthesis of a Gramicidin S Analog Containing δ-Aminovaleric Acid, [4–5-δ-Aminovaleric Acid]-Gramicidin S
- Studies on the Secondary Structure of Bradykinin in Aqueous Solution. Syntheses, Circular Dichroism Spectra, and Biological Activities of Bradykinin Analogs Containing 5-Aminovaleric Acid Residue.
- Synthesis of gramicidin S(GS) analogs, (3-4-.DELTA.Ava)-GS and (3-4,3'-4'-bis(.DELTA.Ava))-GS (.DELTA.Ava=5-aminovaleric acid).
- Sialogogic Effects of Rat Submandibular Gland of Analogs of the C-Terminal Hexapeptide of Substance P.
- Solid-phase synthesis of C-terminal hexapeptide analogs of substance P.