Synthesis of gramicidin S(GS) analogs, (3-4-.DELTA.Ava)-GS and (3-4,3'-4'-bis(.DELTA.Ava))-GS (.DELTA.Ava=5-aminovaleric acid).
スポンサーリンク
概要
- 論文の詳細を見る
Gramicidin S (GS) analogs, [δAva<SUP>3–4</SUP>]–GS and [δAva<SUP>3–4,3′–4′</SUP>]–GS, were synthesized. Both of these peptides are analogs in which one or two L-leucyl-D-phenylalanyl residues of GS are replaced by one or two 5-aminovaleric acid residues. The CD spectrum of the mono-substituted analog has two troughs as that of GS. However, this analog showed almost no antimicrobial activity. Moreover, the di-substituted analog showed a CD spectrum that is ascribed to a random structure and had no antimicrobial activity.
- 公益社団法人 日本化学会の論文
著者
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Sofuku Shosuke
Department Of Chemistry College Of Science Rikkyo University
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Muramatsu Ichiro
Department Of Chemistry College Of Science Rikkyo University
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Sugiyama Yasutaro
Department of Chemistry, College of Science, Rikkyo University
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