Studies on the .BETA.-turn of peptides. II. Syntheses and conformational properties of N-(2,4-dinitrophenyl)tetrapeptide p-nitroanilides related to the .BETA.-turn part of gramicidin S.
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概要
- 論文の詳細を見る
<I>N</I>-(2,4-Dinitrophenyl)tetrapeptide <I>p</I>-nitroanilides related to the β-turn part of gramicidin S were synthesized and subjected to CD measurements. The β-turn preference of the tetrapeptide derivatives had correlation with the antibiotic activities of the gramicidin S analogs containing similar tetrapeptide sequences at their β-turn part. So, conformational preference of partial sequences of gramicidin S analogs seem to play a significant role for determining their biological activities.
- 公益社団法人 日本化学会の論文
著者
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Sato Kazuki
Mitsubishi Kasei Institute Of Life Sciences
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Kawai Masao
Mitsubishi-Kasei Institute of Life Sciences
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Nagai Ukon
Mitsubishi-Kasei Institute of Life Sciences
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