Studies on the .BETA.-turn of peptides. V. Turn preference of peptide sequences analyzed by conformational energy calculation on dipeptide models and by CD spectra of chromophoric derivatives.
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概要
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Empirical conformational energy calculations were performed on Ac–L-Pro–D-Ala–NHCH<SUB>3</SUB> and Ac–D-Ala–L-Pro–NHCH<SUB>3</SUB>. In order to study the turn tendency of the dipeptide sequences turn probabilities and average interterminal distances were calculated. Much larger turn preference of D-Ala containing sequences was indicated compared with the corresponding L-Ala containing sequences. The turn tendency of the dipeptide sequences were shown to be in the order: L-Pro–D-Ala>D-Ala–L-Pro>L-Pro–L-Ala>L-Ala–L-Pro. This order coincides with the order of the magnitude of the Cotton effects in the CD spectra of the chromophoric derivatives having 2,4-dinitrophenylglycyl and glycine-<I>p</I>-nitroanilide at the <I>N</I>- and the <I>C</I>-termini, respectively, of the corresponding dipeptid esequences. This agreement supports the validity of the chiroptical method to study the turn tendency of the peptide sequences using chromophoric derivatives reported earlier.
- 公益社団法人 日本化学会の論文
著者
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Sato Kazuki
Mitsubishi Kasei Institute Of Life Sciences
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Nagai Ukon
Mitsubishi-Kasei Institute of Life Sciences
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Kawai Masao
Department of Appliced Chemistry, Nagoya Institute of Technology
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Sugawara Rika
Mitsubishi-Kasei Institute of Life Sciences
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