Studies on .BETA.-turn of peptides. XII. Synthetic confirmation of weak activity of (D-Pro5,5')-gramicidin S predicted from .BETA.-turn preference of its partial sequence.
スポンサーリンク
概要
- 論文の詳細を見る
[D-Pro<SUP>5,5′</SUP>]-Gramicidin S was synthesized to confirm a prediction that D-D sequence at the corner position had low preference for β-turn. The analog showed much weaker activity than gramicidin S and also showed different CD spectra from those of gramicidin S. The results indicate that the analog can not take stable, gramicidin S-like, β-sheet conformation.
- 公益社団法人 日本化学会の論文
著者
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Kato Rika
Mitsubishi Kasei Institute Of Life Sciences
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Sato Kazuki
Mitsubishi Kasei Institute Of Life Sciences
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Nagai Ukon
Mitsubishi-Kasei Institute of Life Sciences
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