Rosenthal管の破壊と蝸牛管各細胞の変化

概要

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Some pathological changes in the cochlea are difficult to reproduce in animal experiments, therefore related data are few. Primary spiral ganglion loss and selective blockade of the blood supply in the cochlear duct are examples of the aforementioned changes.A pair of temporal bones with tumor invasion into the modiolus from the internal auditory canals was studied as a model of such subjects.Totally replaced spiral ganglion cells by the tumor in the basal turns were used as a model of primary nerve degeneration as compared to the intact upper turns. Secondary hair cell degeneration was observed in regions only where tumor cells had invaded and destroyed the ganglion cells. Inner hair cells resisted the invasion more than did the outer cells.Stria vascularis was intact in the entire length of the cochlear duct, except at the basal ends where the tumor invasion reached radiating arterioles. Our finding supported Lawrence's opinion that the cochlear duct was nourished by two independent vascular systems of the external and internal radiating arterioles.
耳鼻咽喉科臨床学会の論文