The effect of vitamin D deficiency on cochlear potentials of rats.

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It has been reported that sensorineural hearing loss is frequently observed in patients with renal failure. This phenomenon has been confirmed in animal experiments by Ikeda et al (1985). It is known that Ca metabolism is disturbed in cases of renal failure. The present study was designed to determine whether disturbance of Ca metabolism have any effect on cochlear function.Cochlear potentials were measured in 19 rats on a vitamin D deficient diet. Serum Ca2+ concentrations were about half of the normal value, and the rats lost weight on this diet.N1 was elicited by click of stimuli and filtered tone bursts of 2, 4, 8 and 12kHz. Narrow-band analysis was performed by low-cut masking, and responses above 8kHz, from 4 to 8kHz 2 to 4kHz were recorded. CM was evoked by filtered tone bursts.As the vitamin D deficient diet continued, N1 latency prolongation, depression of CM amplitude and elevation of CM threshold increased. The latency of narrowband APs was prolonged in most regions of the cochlear partition, but the N1 amplitude and threshold did not change.It is considered that the influence of Ca2+, parathyroid hormone and vitamin D on the cochlea caused these changes in cochlear potentials.
耳鼻咽喉科臨床学会の論文