Effects of Bifemelane Hydrochloride on the Outer Hair Cells.

概要

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The intracellular free calcium concentration ([Ca2+]i) in the cochlear outer hair cells (OHC) of the guinea pig was measured with a microfluorimetric imaging technique and the effects of free radicals and bifemelane hydrochloride were investigated. The application of hypoxanthine (HX) plus xanthine oxidase (XO) to the OHC resulted in an increase in [Ca2+]i. in the presence of external Ca2+. Elimination of external Ca2+ did not cause an increase in [Ca2+]i . The elevation of [Ca2+]i induced by HX-XO was reduced by the addition of superoxide dismutase. These findings indicate that superoxide anions generated in the OHC increase Ca2+ influx across the membrane. Administration of bifemelane hydrochloride significantly inhibited the increase in [Ca2+]i induced by HX-XO, suggesting that bifemelane has a therapeutic effect on pathological events in the OHC.
耳鼻咽喉科臨床学会の論文