Saccular and Cochlear EP in Animals with Hydrops

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It is well known that the saccular endolymphatic potential (SEP) in normal animals is not produced in the saccule per se but by a leak from the cochlear endolymphatic potential (CEP). The present study examines the relationship between CEP and SEP in animals with hydrops. Endolympahtic hydrops was induced by obliterating the endolymphatic sac in 33 animals and the potential was measured 2 weeks, 1 month and 3 months postoperatively.CEP was already slightly reduced at 2 weeks and was 56.0±15.1mV and 54.8±13.1mV (normal value 87.2±5.3mV) at 1 and 3 months, respectively. SEP was also reduced to -0.2±3.5mV and -1.0±1.9mV (normal value 5.0±3.5mV) at 1 and 3 months, respectively. As the magnitudes of the potentials were reduced, the response to ischemia was decreased, namely a delayed decline and slow rate of decline, indicating a reduced metabolic rate in the stria vasculalis. In the early stage of hydrops, the magnitude of SEP reduction in asphyxia was about 10% that of CEP, as in normal animals. Later, however, the reduction of SEP became much less and finally it was slightly increased during asphyxia even though CEP was reduced. It was concluded that CEP was not transmitted to the saccule in case of ears with advanced hyrdrops.
耳鼻咽喉科臨床学会の論文