赤外線凝固装置の鼻粘膜への効果--鼻粘膜修復過程の走査電顕的観察

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Animal experiments were performed to evaluate the clinical efficacy of three hemostatic instruments.: the infrared contact coagulator (I. C. C.), the YAG laser and the conventional electrocoagulator.Under general anesthesia with i. v. Nembutal, the maxillary antrums of rabbits were exposed surgically and the hemostatic instrument was applied to the antral wall to coagulate the mucous membrane. After coagulation, the mucous membranes were removed immediately and 3, 6, 9, and 14 days post-operatively. The specimens were fixed in 2.5% glutaraldehyde in 0.1M phosphate buffer, post-osmificated, and observed under a scanning electron microscope (H-450).The specimens coagulated with the three instrument did not differ significantly. Irradiation with the I. C. C. for 1.0-1.5 seconds thoroughly coagulated even the deep tissue of the lamina propria, leaving sharp margins between the irradiated zone and the non-irradiated pseudostratified ciliated epithelium.Regeneration of the epithelial cells in the irradiated zone started within 3 post-operative days by basal cell transformation towards the non-epithelial portion. On the 6th postoperative day, the irradiated area was completely covered by cuboidal cells, and some non-ciliated cells with short microvilli were visible in the marginal zone. The ciliated cells were still sparse at 6 days, but they gradually increased in number thereafter. On the 10th postoperative day, the irradiated portion was completely covered with almost normal pseudostratified ciliated epithelium.These results show that the I. C. C. is a useful hemostatic instrument in cases of anterior nasal hemorrhage.
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赤外線凝固装置の鼻粘膜への効果--鼻粘膜修復過程の走査電顕的観察

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