前庭神経内側核の同側前庭神経外側核に対する影響--電気生理学的,Horseradish Peroxidase法による研究 (京都大学医学部耳鼻咽喉科学教室6年間の歩み(1977-1982年)--檜学教授還暦によせて)

概要

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An electrophysiological study was performed to determine whether or not there were direct effects from the medial vestibular nucleus (MVN) on neurons in the ipsilateral lateral vestibular nucleus (LVN) of cats anesthetized with α-chloralose. Moreover, the fiber connection from the MVN to the LVN was examined using the retrograde horseradish peroxidase (HRP) method.When the stimulus was applied to the MVN, there was monosynaptic spike generation in 18 out of the 75 LVN neurons which were monosynaptically activated by vestibular nerve stimulation. In the other 11 LVN neurons, the monosynaptic spike generation with vestibular nerve stimulation was inhibited by the conditioning stimuli applied to the MVN preceding the test stimulus. When the stimulus was applied to the LVN, an antidromic spike was obtained in 12 out of the 45 MVN neurons which were monosynaptically activated by vestibular nerve stimulation.When HRP was iontophoretically applied to the immediate vicinity of the LVN neuron monosynaptically excited by vestibular nerve stimulation, HRP-labeled cells were found in the MVN.These findings suggest that there exist direct fiber connections from the MVN to the LVN and that some of the MVN neurons are playing a role of regulating the LVN neurons, thereby controlling the posture and/or vestibular reflex.
耳鼻咽喉科臨床学会の論文