Effects of Prednisolone on Neuronal Activity of Medial Vestibular Neucleus

概要

論文の詳細を見る
The effects of prednisolone on the neurons in the medial vestibular nucleus (MVN) were investigated by electrophysiological methods in anesthetized cats, since the drug is known to be effective in the treatment of vertigo in some diseases, such as Meniere's disease. Extracellular neuronal activity in the MVN recorded with a glass-insulated silver wire microelectrode attached along a seven-barreled micropipette containing prednisolone hydrochloride (0.1 M), monosodium glutamate (1 M), glutamic acid diethylester (0.05 M), or CoCl<SUB>2</SUB> (0.1 M). These chemicals were applied microiontophoretically to the target neuron being recorded. The MVN neurons were classified as type I or type II neurons according to their responses to horizontal and sinusoidal rotation. The effects of the drugs on type I neurons were examined. The intravenous injection of prednisolone up to 5 mg/kg induced an increase in spontaneous and rotation-induced firing in 5 of 7 neurons tested. Microiontophoretically applied prednisolone in doses of 50-200 nA dose-dependently increased spontaneous and rotation-induced firing in 19 of 25 neurons examined ; the firing of 5 of the remaining 6 neurons was unaffected by the drug up to 200 nA, and in only one neuron it was decreased. Prednisolone-induced increase in firing of the MVN neurons was not affected by the iontophoretic application of GDEE, which inhibited glutamate-and rotation-induced firing. Microiontophoretically applied Co<SUP>2+</SUP>" did not affect prednisolone-, glutamate-, or rotation-induced firing. These results suggest that prednisolone acts directly on the MVN neuron membrane and activates neuronal excitability.
日本めまい平衡医学会の論文

Effects of Prednisolone on Neuronal Activity of Medial Vestibular Neucleus

スポンサーリンク

概要

著者

関連論文

スポンサーリンク