魚類の脂肪酸代謝に関する研究-6-コイの肝膵臓と血合肉ミトコンドリアにおける16:0酸のβ-酸化による生成物

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The products formed by β-oxidation were studled in carp (Cyprinus carpio) hepatopancreas and dark muscle mitochondria by using 14C-16:0 acid.16:0 acid was converted primarily to CO2 and water soluble compounds by β-oxidation in carp dark muscle mitochondria. The incorporation of 16:0 acid into triglyceride and phospholipid was extremely slight in the mitochondria. These results suggested that 16:0 acid participated in β-oxidatlon in preference to a synthesis of lipids in tho system. The water soluble compounds acetic, fumaric, and succinic acids were identified in carp hepatopancreas and dark muscle mitochondria as well as in rat liver mitochondria. Among these, acetic acid was predominant in all of the mitochondria. Moreover, the amounts of fumaric and succinic acids, intermediates of the TCA cycle, produced in carp hepatopancreas were not so great as those in carp dark muscle and rat liver. β-Hydroxybutyric acid was clearly detected byβ-oxidation of 16:0 acid in carp hepatopancreas as well as in rat liver, but is was only slightly detected in carp dark muscle. Consequently, the author concluded that the difference in β-oxidation of 16:0 acid between carp hepatopancreas and dark muscle mitochondria might arise from the formation of a ketone body by β-oxidation in hehatopancreas mitochondria.
日本水産學會の論文