魚類の脂肪酸代謝に関する研究-2-コイ肝膵臓ミトコンドリアにおける脂肪酸のβ-酸化系に関与する因子

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A study was done on cofactors which may effect the activity of the β-oxidation in carp (Cyprinus carpio) hepatopancreas mitochondria. Finding that carnitine, CoA, ATP and Mg++ accelerated the 02 uptake, an improved medium was devised for the further study of the β-oxidation system. In the improved medium the 02 uptake was 4.7 times that of the original one, while the endogenous respiration remained almost unchanged. Removal of CoA and carnitine from the improved medium resulted in a considerable decrease of the 02 uptake suggesting that the activation of fatty acids and the permeation of the activated acids through the membrane are probably the initial stages of the β-oxidation phenomenon. Moreover, the 02 uptake in the improved medium was not affected until the sample mitochondria was left at 0°C for 12 hours.
日本水産學會の論文