魚体成分の抗菌作用に関する研究-VIII : 酸化魚油中の抗菌性物質の分別

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In the present work, the stability of the antibiotic autoxidized fish oils and the fractionation of an antibiotic substance have been studied, and the following results were obtained. 1) The antibiotic autoxidized fish oils are not stable to thermal treatment by which further oxidation is promoted. They are also unstable to alkaline treatment, but stable to ultraviolet radiation. 2) An antibiotic substance could not be fractiona ?? d by the vacuum or steam distillation. The urea segregation has been found to be a useful technique for the fractionation of it. 3) An antibiotic substance, contained in autoxidized fatty acids or methyl esters derived from shark liver oils, was concentrated into petroleum ether soluble fraction which do dot form urea complex. Further purification was carried out by chromatography using activated charcoal and petroleum ether.