Seasonal Changes in Immunoreactivity of Activin Signaling Component Proteins in Wild Ground Squirrel Testes
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概要
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The seasonal spermatogenesis and localization of inhibin/activin subunits (alpha, betaA, betaB) in the testes of wild ground squirrel has been previously described; however, the expression pattern of activin receptors and cytoplasmic signaling SMADs has not been detected in any seasonal breeders. The objective of this study was to investigate the abundance and cellular localization of activin signaling components in testes of the wild ground squirrel during the breeding and nonbreeding seasons. The immunolocalizations of ActRIIB (activin type II receptor B) and activin-related SMADs (phospho-SMAD2/3, SMAD4 and SMAD7) were observed by immunohistochemistry. Total proteins were extracted from testicular tissues in the breeding and nonbreeding seasons and were used for Western blotting analysis for ActRIIB and SMADs. Immunoreactivities of activin signaling components were greater in the testes of the breeding season, and then decreased to a relatively low level in the nonbreeding season. ActRIIB and related SMADs were widely spread in the active testes, while spermatogonia were the predominant cellular sites of activin signal transduction during arrested spermatogenesis. The dynamic regulation of activin type II receptor and SMADs indicated that the activin signal pathway played an important paracrine role in seasonal spermatogenesis of the wild ground squirrel. Furthermore, the distinct localizations and immunoreactivity of ActRIIB and SMADs might suggest different functions of activin in seasonal spermatogenesis.
著者
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Zhang Mengyuan
College Of Biological Science And Technology Beijing Forestry University
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Taya Kazuyoshi
Laboratory Of Veterinary Physiology Department Of Veterinary Medicine Faculty Of Agriculture Tokyo U
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Xu Meiyu
College Of Biological Science And Technology Beijing Forestry University
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Sheng Xia
College Of Biological Science And Technology Beijing Forestry University
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Weng Qiang
College Of Biological Science And Technology Beijing Forestry University
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Zhang Haolin
College Of Biological Science And Technology Beijing Forestry University
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Song Moshi
College Of Biological Science And Technology Beijing Forestry University
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Hu Xiao
College Of Biological Science And Technology Beijing Forestry University
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Zhang Wei
College Of Biological Science And Technology Beijing Forestry University
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Watanabe Gen
Laboratories Of Veterinary Physiology Dep. Of Veterinary Medicine Fac. Of Agriculture Tokyo Univ. Of
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ZHOU Jiao
College of Biological Science and Technology, Beijing Forestry University, Beijing 100083, China
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Zhou Jiao
College Of Biological Science And Technology Beijing Forestry University
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WENG Qiang
College of Biological Science and Technology, Beijing Forestry University, Beijing 100083, China
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HU Xiao
College of Biological Science and Technology, Beijing Forestry University, Beijing 100083, China
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TAYA Kazuyoshi
Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan
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XU Meiyu
College of Biological Science and Technology, Beijing Forestry University, Beijing 100083, China
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ZHANG Mengyuan
College of Biological Science and Technology, Beijing Forestry University, Beijing 100083, China
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ZHANG Wei
College of Aerospace and Materials Engineering, National University of Defense Technology
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ZHANG Wei
College of Biological Science and Technology, Beijing Forestry University, Beijing 100083, China
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