Vitamin E Reduces Glucocorticoid-Induced Growth Inhibition and Lipid Peroxidation in Rats
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概要
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This experiment was conducted to study the effects of vitamin E on growth inhibition and lipid peroxidation in rats treated with different levels of corticosterone (CTC). Rats (Sprague-Dawley strain, 5 weeks of age) were divided into two groups: control group receiving a basal diet containing 60 mg DL-α-tocopheryl acetate/kg diet, and vitamin E group receiving the same diet supplemented with 5, 000 mg tocopherol. After 6 days, rats of both diet groups were further divided into three groups by dose levels of CTC treatment (0, 25, and 100mg CTC/kg body weight/d). CTC was administered to the rats by subcutaneous injection for 4 d. Growth was dose-dependently inhibited by the CTC treatment. Feeding the vitamin E diet significantly (p<0.05) improved growth retardation. Feed efficiency was lowered by CTC treatment, while this was significantly (p<0.05) minimized by feeding the vitamin E diet. Lipid peroxidation (TBARS) in the liver was elevated by the CTC treatment (p<0.001) when the rats were fed the basal diet. The increment in TBARS was significantly (p<0.001) reduced by vitamin E. The activities of glutathione S-transferase (GST) and superoxide dismutase (SOD) were significantly reduced by the CTC treatment in a dose-dependent manner in both dietary groups. Feeding vitamin E significantly (p<0.001) improved the reduction in GST activity. The SOD activity showed some tendency. The present results demonstrate the effectiveness of vitamin E in improving growth retardation in glucocorticoid-treated rats and suggest that reductions in increased lipid peroxidation due to CTC may be an important factor of the action of vitamin E.
- 財団法人 学会誌刊行センターの論文
著者
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Ohtsuka Akira
Dep. Of Biochemical Sci. And Technol. Fac. Of Agriculture Kagoshima Univ. Jpn
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Ohtsuka Akira
Department Of Biochemical Science And Technology Faculty Of Agriculture Kagoshima University
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Hayashi Kunioki
Department Of Biochemical Science And Technology Faculty Of Agriculture Kagoshima University
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Ohtani Takayuki
Department Of Emergency Medicine St.luke's International Hospital
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Kojima Hiroshi
Department Of Clinical Oncology Ibaraki Prefectural Central Hospital
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HORIGUCHI Hirohisa
Department of Biochemical Science & Technology, Faculty of Agriculture
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HORIGUCHI Hirohisa
Department of Biochemical Science & Technology, Faculty of Agriculture
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OHTSUKA Akira
Department of Biochemical Science & Technology, Faculty of Agriculture
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HAYASHI Kunioki
Department of Biochemical Science & Technology, Faculty of Agriculture
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OHTANI Takayuki
Department of Biochemical Science & Technology, Faculty of Agriculture
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