Calcitonin Decreases Corticosterone-induced Skeletal Muscle Calpain Activity
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概要
- 論文の詳細を見る
The effects of calcitonin (CT) administration on calcium (Ca) concentrations in plasma and skeletal muscle as well as the calpain activity of skeletal muscle were examined in young growing male rats treated with corticosterone (CTC). The rats received subcutaneous injections of CTC (5mg/100g body weight/day), or both CTC and CT (100m unit/100g body weight/day) for four days. Control rats received placebos. The rats were sacrificed 24 h after the final injections, and blood was taken followed by dissections to remove gastrocnemius and extensor digitorum longus muscles. Plasma Ca concentration was increased and muscle Ca concentration and its calpain activity tended to be increased by CTC. The CTC-induced increases in muscle Ca concentration and its calpain activity were significantly minimized by the simultaneous injection of CT. However, CTC-induced hypercalcemia was not minimized by CT. The present observations indicate that CT decreases Ca concentration in skeletal muscle cell and its calpain activity, followed by a suppression of muscle proteolysis in rats treated with CTC.
- 財団法人 学会誌刊行センターの論文
著者
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Higuchi Kouji
Department Of Biochemical Science And Technology Faculty Of Agriculture Kagoshima University
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Ohtsuka Akira
Dep. Of Biochemical Sci. And Technol. Fac. Of Agriculture Kagoshima Univ. Jpn
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Ohtsuka Akira
Department Of Biochemical Science And Technology Faculty Of Agriculture Kagoshima University
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Tomita Yuichiro
Department Of Pediatrics For Structure And Function Research Tokai University School Of Medicine
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Hayashi K
Department Of Biochemical Sciences Kagoshima University
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Hayashi Kunioki
Department Of Biochemical Science And Technology Faculty Of Agriculture Kagoshima University
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TOMITA Yuichiro
Department of Biochemical Science and Technology, Faculty of Agriculture, Kagoshima University
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OHTSUKA Akira
Department of Biochemical Science & Technology, Faculty of Agriculture
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Hayashi Kunioki
Department of Biochemical Science and Technology, Faculty of Agriculture, Kagoshima University
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HAYASHI Kunioki
Department of Biochemical Science & Technology, Faculty of Agriculture
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TOMITA Yuichiro
Department of Animal Science, Faculty of Agriculture, Kagoshima University
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