Detection of circulating CEA-IgM complexes in early stage gastric cancer
スポンサーリンク
概要
- 論文の詳細を見る
Background: The early detection of gastric cancer is important issue for improving the survival rate. As a serum marker, Carcinoembryonic antigen (CEA) and CA19-9 in serum is widely used. But their limited sensitivity is not suiTable for screen method.Methods: In this study, titer of CEA-IgM complexes was measured in serum from 86 patients with primary gastric cancer who underwent surgery. 48 of the tumors (56%) were Stage IA, 10 (12%) were Stage IB, 6 (7%) were Stage II, 11 (13%) were Stage III, 11 (13%) were Stage IV. Serum samples from 23 patients found to have no tumors with gastritis were analyzed as non-gastric cancer group. In each serum sample, CEA and CEA-IgM complexes were measured.Results: By CEA-IgM tests, overall sensitivity was 20% (17/86), Stage IA 19% (9/48), Stage IB 30% (3/10), Stage II 0% (0/6), Stage III 17% (3/11) and Stage IV 2% (2/11), while false positive rate was 9% (2/23). By conventional CEA test, overall sensitivity was 5% (4/86), with Stage IA, IB 2% (1/58). Moreover, CEA-IgM complexes detected differentiated adenocarcinoma with overall sensitivity 38% (11/29), more than undifferentiated adenocarcinoma of gastric cancer.Conclusion: CEA-IgM might open a new possibility of detecting gastric cancer by serum in early stages, especially of differentiated adenocarcinoma.
著者
-
Kodera Yasuhiro
Department Of Materials Chemistry Innovative Materials And Processing Research Center Ryukoku Univer
-
Matsui Takanori
Department Of Gastroenterological Surgery Aichi Cancer Center Aichi Hospital
-
Kojima Hiroshi
Department Of Clinical Oncology Ibaraki Prefectural Central Hospital
-
Kojima Taiki
Kojima family clinic
-
Matsui Takanori
Department of Gastroenterological Surgery, Aichi Cancer Center Aichi Hospital
関連論文
- Gastric T-cell lymphoma with cytotoxic phenotype
- A polymorphism of C-to-T substitution at -31 IL1B is associated with the risk of advanced gastric adenocarcinoma in a Japanese population
- OE-091 Involvement of Membrane Type 1-Matrix Metalloproteinase (MT1-MMP) in Advanced Glycation End Products (AGE)/RAGE-Signaling Pathways(OE16,Diabetes (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Effective and Safe Interferon Treatment for Japanese Patients With Chronic Myelogenous Leukemia Relapse After Bone Marrow Transplantation
- A phase I radioimmunolocalization trial of humanized monoclonal antibody huA33 in patients with gastric carcinoma
- Does the control of alanine aminotransferase levels lead to a regression of liver fibrosis in chronic hepatitis C patients?
- Changes of liver fibrosis in chronic hepatitis C patients with no response to interferon-α therapy: including quantitative assessment by a morphometric method
- Parameters predicting response to ursodeoxycholic acid therapy in chronic hepatitis C
- Quinupristin/dalfopristin and voriconazole controlled Staphylococcus epidermidis pneumonia and chronic necrotizing aspergillosis in a patient with severe lung degradation consequent to multiple treatments for Hodgkin's lymphoma
- Targeted delivery of oligomannose-coated liposome to the omental micrometastasis by peritoneal macrophages from patients with gastric cancer
- Quality of Life in Adult Patients After Stem Cell Transplantation
- Quality of Life in Adult Patients after Bone Marrow Transplantation
- Requirement of the tyrosines at residues 258 and 270 of MAIR-I in inhibitory effect on degranulation from basophilic leukemia RBL-2H3
- In vitro chemosensitivity test to predict chemosensitivity for paclitaxel, using human gastric carcinoma tissues
- Laparoscopic Wedge Resection for Gastrointestinal Stromal Tumors of the Stomach : Initial Experience
- A New Method of Thermo-chemotherapy Using a Stent for Patients with Esophageal Cancer
- Prolonged cytostatic tumor dormancy induced by serial exchange of chemotherapy in colorectal carcinoma
- A Peptic Ulcer in a Reconstructed Gastric Tube Perforating the Thoracic Aorta after Esophageal Replacement
- Chemosensitivity of peritoneal micrometastases as evaluated using a green fluorescence protein (GFP)-tagged human gastric cancer cell line
- Use of Sample Hematocrit Value to Correct Blood Tacrolimus Concentration Derived by Microparticle Enzyme Immunoassay(Highlighted paper selected by Editor-in-chief,Miscellaneous)
- Lymph Node Metastasis in Cancer of the Middle-Third Stomach : Criteria for Treatment with a Pylorus-Preserving Gastrectomy
- Detection of Carcinoembryonic Antigen-expressing Free Tumor Cells in Peritoneal Washes from Patients with Gastric Carcinoma by Polymerase Chain Reaction
- Gastric Cancer with Carcinoma Erysipeloides Caused by Spontaneous Thoracic Duct Rupture: Report of a Case
- Matrix Metalloproteinase 9 in Human Plasma Has 96% Specificity and 56% Sensitivity for Gastric Cancer Screening
- Small Incisional Esophagectomy with Endoscopic Assistance : Evaluation of a New Technique
- The Ratio of Splicing Variants of MGC-24/CD164, a Sialomucin, Correlates with the Metastatic Protential of Colorectal Carcinomas
- Detection of circulating CEA-IgM complexes in early stage gastric cancer
- Titration of serum CEA, p53 antibodies and CEA-IgM complexes in 142 patients with colorectal cancer and 150 healthy blood donors.
- Ultrastructural changes at the myotendinous junction induced by exercise
- K Shell Excitations for Boron and Fluorine by Heavy and Light Ion Bombardments
- Angular Distributions of K-Shell Auger Electrons for Carbon, Nitrogen, Oxygen and Neon Excited by Energetic Ions
- Auger Electrons from Zinc and Cadmium Vapors by Proton and Alpha Particle Bombardments
- The Effectiveness of Medroxyprogesterone in the Treatment of Multiple Metastasizing Leiomyosarcomas : Report of a Case
- Turbostratic boron nitride consolidated by SPS
- Influence of pulsed DC current and electric field on growth of carbide ceramics during spark plasma sintering
- Enhanced Growth of Mo_2C formed in Mo-C Diffusion Couple by Pulsed DC Current
- Feasibility study of direct fentanyl patch introduction without prior opioid titration
- Topical application of anti-angiogenic peptides based on pigment epithelium-derived factor can improve psoriasis
- Clinical evaluation of a light-activated glass-ionomer fissure sealant
- Characterization of a novel lymph node metastasis model from human colonic cancer and its preclinical use for comparison of anti-metastatic efficacy between oral S-1 and UFT/LV
- Immunohistochemical Examination on the Distribution of Cells Expressed Lymphatic Endothelial Marker Podoplanin and LYVE-1 in the Mouse Tongue Tissue
- Major anatomical hepatic resection with regional lymph node dissection for liver metastases from colorectal cancer
- Measurement of Electron Cyclotron Emission in JIPP T-II
- Circadian Rhythm-Modulated Chemotherapy with High Dose 5-Flourouracilagainst Gastrointestinal Cancers: Evaluation and Case Report
- Adherence to the standard dose of imatinib, rather than dose adjustment based on its plasma concentration, is critical to achieve a deep molecular response in patients with chronic myeloid leukemia
- Vitamin E Reduces Glucocorticoid-Induced Oxidative Stress in Rat Skeletal Muscle
- Vitamin E Reduces Glucocorticoid-Induced Growth Inhibition and Lipid Peroxidation in Rats
- Modified FOLFOX6 with oxaliplatin stop-and-go strategy and oral S-1 maintenance therapy in advanced colorectal cancer : CCOG-0704 study
- Successful Treatment of HTLV-1-Related Overlap Syndrome Using Tacrolimus
- Appropriate interruption of cetuximab may balance efficacy and toxicity: a case of long-term treatment with FOLFIRI plus cetuximab
- Distribution of Podoplanin-Expressing Cells in the Mouse Nervous Systems
- Immunoelectron Microscopic Study of Podoplanin Localization in Mouse Salivary Gland Myoepithelium