Immunohistochemical Examination on the Distribution of Cells Expressed Lymphatic Endothelial Marker Podoplanin and LYVE-1 in the Mouse Tongue Tissue
スポンサーリンク
概要
- 論文の詳細を見る
The clinical study for lingual disease requires the detailed investigation of the lingual lymphatic network and lymphatic marker-positive cells. Recently, it has been reported that several tissue cells and leukocytes express lymphatic markers, LYVE-1 and podoplanin. This study was aimed to clarify the lingual distribution of cells expressing LYVE-1 and podoplanin. In the mouse tongue, podoplanin is expressed in nerve sheaths, lingual gland myoepithelial cells, and lymphatic vessels. LYVE-1 is expressed in the macrophage marker Mac-1-positive cells as well as lymphatic vessels, while factor-VIII was detected in only blood endothelial cells. α-SMA was detected in vascular smooth muscle and myoepithelial cells. Therefore, identification of lymphatic vessels in lingual glands, the combination of LYVE-1 and factor-VIII, or LYVE-1 and Mac-1 is useful because myoepithelial cells express podoplanin and α-SMA. The immunostaining of factor-VIII on lymphatic vessels was masked by the immunostaining to LYVE-1 or podoplanin because lymphatic vessels express factor-VIII to a far lesser extent than blood vessels. Therefore, except for the salivary glands, the combination of podoplanin and α-SMA, or factor-VIII is useful to identify lymphatic vessels and blood vessels with smooth muscle, or blood capillaries.
著者
-
Hata Minoru
Department Of Orthodontics Osaka Dental University
-
Kojima Hiroshi
Department Of Clinical Oncology Ibaraki Prefectural Central Hospital
-
Sawa Yoshihiko
Department Of Gastroenterology And Hepatology Nara City Hospital
-
Noda Yuya
Department of Oral Growth & Development, Fukuoka Dental College
-
Amano Ikuko
Department of Oral Growth & Development, Fukuoka Dental College
-
Noda Yuya
Department of Oral Growth & Development, Fukuoka Dental College
-
Amano Ikuko
Department of Oral Growth & Development, Fukuoka Dental College
関連論文
- Relapse of hepatitis C in a pegylated-interferon-α-2b plus ribavirin-treated sustained virological responder
- Gastric T-cell lymphoma with cytotoxic phenotype
- Effective and Safe Interferon Treatment for Japanese Patients With Chronic Myelogenous Leukemia Relapse After Bone Marrow Transplantation
- Does the control of alanine aminotransferase levels lead to a regression of liver fibrosis in chronic hepatitis C patients?
- Changes of liver fibrosis in chronic hepatitis C patients with no response to interferon-α therapy: including quantitative assessment by a morphometric method
- Parameters predicting response to ursodeoxycholic acid therapy in chronic hepatitis C
- Quinupristin/dalfopristin and voriconazole controlled Staphylococcus epidermidis pneumonia and chronic necrotizing aspergillosis in a patient with severe lung degradation consequent to multiple treatments for Hodgkin's lymphoma
- Helicobacter pylori-negative gastric and duodenal ulcers
- Quality of Life in Adult Patients After Stem Cell Transplantation
- Quality of Life in Adult Patients after Bone Marrow Transplantation
- Requirement of the tyrosines at residues 258 and 270 of MAIR-I in inhibitory effect on degranulation from basophilic leukemia RBL-2H3
- Use of Sample Hematocrit Value to Correct Blood Tacrolimus Concentration Derived by Microparticle Enzyme Immunoassay(Highlighted paper selected by Editor-in-chief,Miscellaneous)
- Non-prescription supplement-induced hepatitis with hyperferritinemia and mutation (H63D) in the HFE gene
- Detection of circulating CEA-IgM complexes in early stage gastric cancer
- Titration of serum CEA, p53 antibodies and CEA-IgM complexes in 142 patients with colorectal cancer and 150 healthy blood donors.
- Ultrastructural changes at the myotendinous junction induced by exercise
- K Shell Excitations for Boron and Fluorine by Heavy and Light Ion Bombardments
- Angular Distributions of K-Shell Auger Electrons for Carbon, Nitrogen, Oxygen and Neon Excited by Energetic Ions
- Auger Electrons from Zinc and Cadmium Vapors by Proton and Alpha Particle Bombardments
- The Effectiveness of Medroxyprogesterone in the Treatment of Multiple Metastasizing Leiomyosarcomas : Report of a Case
- Effect on the Dentofacial Complex of Macaca irus of Functional Tongue Forces Imparted on a Palatal Bar : Tongue Forces Imparted on Palatal Bar
- Feasibility study of direct fentanyl patch introduction without prior opioid titration
- Clinical evaluation of a light-activated glass-ionomer fissure sealant
- Immunohistochemical Examination on the Distribution of Cells Expressed Lymphatic Endothelial Marker Podoplanin and LYVE-1 in the Mouse Tongue Tissue
- Measurement of Electron Cyclotron Emission in JIPP T-II
- New trends in the study of podoplanin as a cell morphological regulator
- Circadian Rhythm-Modulated Chemotherapy with High Dose 5-Flourouracilagainst Gastrointestinal Cancers: Evaluation and Case Report
- Adherence to the standard dose of imatinib, rather than dose adjustment based on its plasma concentration, is critical to achieve a deep molecular response in patients with chronic myeloid leukemia
- Vitamin E Reduces Glucocorticoid-Induced Oxidative Stress in Rat Skeletal Muscle
- Vitamin E Reduces Glucocorticoid-Induced Growth Inhibition and Lipid Peroxidation in Rats
- Immunohistochemical Examination of Novel Rat Monoclonal Antibodies against Mouse and Human Podoplanin
- Successful Treatment of HTLV-1-Related Overlap Syndrome Using Tacrolimus
- Expression of Toll-Like Receptor 4 in Glomerular Endothelial Cells under Diabetic Conditions
- Altered Dynamics in the Renal Lymphatic Circulation of Type 1 and Type 2 Diabetic Mice
- Appropriate interruption of cetuximab may balance efficacy and toxicity: a case of long-term treatment with FOLFIRI plus cetuximab
- Distribution of Podoplanin-Expressing Cells in the Mouse Nervous Systems
- Induction of ICAM-1 and VCAM-1 on the Mouse Lingual Lymphatic Endothelium with TNF-.ALPHA.
- Immunoelectron Microscopic Study of Podoplanin Localization in Mouse Salivary Gland Myoepithelium