Antioxidative Mechanism and Apoptosis Induction by 3-Hydroxyanthranilic Acid, an Antioxidant in Indonesian Food Tempeh, in the Human Hepatoma-Derived Cell Line, HuH-7

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概要

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• Recently, a new potent antioxidant was isolated from Tempeh (a traditional fermented soybean food in Indonesia) and was identified as 3-hydroxyanthranilic acid (HAA). This study deals with the antioxidant mechanism of HAA under biological systems and the cytokill-ing function of HAA to human malignant cells. HAA eliminated free radicals and inhibited the formation of fatty acid hydroperoxide in vitro, suggesting that HAA would serve as an antioxidant in the initial reaction in lipid oxidation systems. Actually, HAA inhibited the formation of the dominant product of membrane lipids, 12-hydroxyeicosatetraenoic acid (12-HETE) at a high concentration, while HAA accelerated 12-HETE formation at a low concentration in mammalian tissue. HAA oxidized glutathione and inhibited superoxide dismutase in vitro. Furthermore, HAA inhibited cell growth and induced apoptosis to HuH-7, a human hepatoma-derived cell line. As long as HAA is taken as a component of Tempeh, and not in large doses as a chemical, it may possibly act as a prooxidant rather than an antioxidant in vivo.

• 財団法人 学会誌刊行センターの論文

著者

• MUTO Yasutoshi

  First Department of Internal Medicine, Gifu University School of Medicine

• Muto Yasutoshi

  First Department Of Internal Medicine Gifu University School Of Medicine

• ESAKI Hideo

  Department of Food and Nutrition, Sugiyama Jogakuen University

• Osawa Toshihiko

  Department Of Applied Physics Tokyo University Of Agriculture And Technology

• MATSUO Masako

  General Education, Gifu Womens University

• NAKAMURA Noriaki

  First Department of Internal Medicine, Gifu University School of Medicine

• SHIDOJI Yoshihiro

  First Department of Internal Medicine, Gifu University School of Medicine

• ESAKI Hideo

  Department of Food and Nutrition, Sugiyama Jyogakuen University

• MATSUO Masako

  General Education, Gifu Women's University

• OSAWA Toshihiko

  Department of Applied Biological Science, Nagoya University

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