ラットの血中グルコース量および肝臓グリコーゲン量におよぼすステビオシド経口投与の影響

概要

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The influence of oral administration of stevioside, which is produced naturally with Stevia rebaudiana Bertoni, on the levels of both blood glucose and liver glycogen of intact rats was investigated. The addition of 0.1% stevioside to a high carbohydrate diet caused a decrease of liver glycogen levels, but not that of blood glucose levels (114±9.4mg/100ml). While rats fed a high fat diet containing 0.1% stevioside had no significant changes in blood glucose and liver glycogen levels, in comparison with those of rats fed a high fat diet alone. Feeding the high carbohydrate diet containing 10% powdered leaves of Stevia (corresponding to about 0.5% stevioside in a diet) caused significant decreases of blood glucose and liver glycogen during 4-week period of feeding. Oral administration of neither stevioside nor Stevia leaves showed any significant changes in rat growth, food intake, food efficiency and relative tissue sizes (liver, thyroid gland and adrenal gland).
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