大腸癌におけるEpidermal Growth Factor Receptor.(EGFR),c-erB-2蛋白同時発現の臨床意義についての研究

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The coexpression of EGFR and c-erbB-2 protein was examined immunohistochemically in a total of 62 freshly frozen specimens of colorectal cancer, and correlations between the coexpression of both receptors and their clinicopathological variables were analyzed.Positive staining of both receptors was found in 21 cases, and it was related to the degree of lymphatic or vascular invasion of cancer cell, the synchronous metastasis to liver or lung, and the most advanced stage (Dukes' D).Moreover, the incidence of the distant metastasis including metachronous metastasis to other organs such as liver, lung or peritoneum were significantly higher in the positive cases of both receptors. These results suggest that the coexpression of EGFR and c-erbB-2 protein may be related to the distant metastasis of colorectal cancer.
財団法人日本消化器病学会の論文