Clinicopathological features of multiple primary cancers of the colon.

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We investigated the clinicopathological features of multiple primary cancers of the colon. Among 374 cases of colon surgery, 29 (7.8 %) were for multiple primary cancers of the colon. The mean patient age was 87.7 years and the ratio of males to females was 2 : 1. In these 29 patients, there was a tendency for malignant disease in their relatives, and stomach cancer predominated over cancers of other organs. There was no particular predisposition for the site of colon cancer. As for the progression of maligncany, stage III or more advanced cases accounted for 66.7 %, which indicated the majority of cases were advanced. The therapeutic results included curative resection in 44.3 %, non-curative resection in 37.3 % and unresectable in 18.4 %. The prognosis was poor, six patients surviving more than three years fater resection of colon cancer, and only two patients surviving for more than five years. It seems that early diagnosis of cancers present in multiple organs is difficult. It is also thought important to investigate patients preoperatively with the presence of multiple cancers in mind, and to observe their clinical course postoperatively.
日本大腸肛門病学会の論文