Quantitative analysis of morphological parameters in the cirrhotic liver using automatic image analizer - The correlation with liver function and Miyake's classification.:The correlation with liver function and Miyake's classification

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This study was undertaken to investigate the relationship between morphological characteristics and hepatic function in cirrhotic patient. Five parameters consist of Mean Area (M.A.) and Shape Facter (S.F.) of lobule or pseudolobule, ratio of fibrotic component to total area (F-Ratio) and Standard Deviation (S.D.) of M.A. and S.F. These parameters were quantitatively analyzed with 90 consecutive liver specimens (77 cirrhotic and 13 normal livers), using Automatic Image Analizer (IBAS-2). Sinfificant difference were observed with these five parameters between cirrhotic and normal livers. However, there were no statistical differences among four categories of liver cirrhosis; A, A', B and B' (Miyake's classification). Among liver function tests, HPT, Alb, ZTT, ICGK and Rmax value showed relatively high correlation ranging from 0.30 to 0.57 with these morphological parameters. On the other hand, both F-RATIO and S.D. of S.F. were relatively in good correlation with liver function tests as compared to other morphological parameters. According to multiple regression analysis to determine the correlation between morphological and functional indices, functional status of cirrhotic liver can be partly assumed by these morphological parameters with multiple correlation coefficient 0.67. It is concluded from these data that computerized morphometric analysis seems to offer an important aspect to evaluate liver cirrhosis.
財団法人日本消化器病学会の論文

Quantitative analysis of morphological parameters in the cirrhotic liver using automatic image analizer - The correlation with liver function and Miyake's classification.:The correlation with liver function and Miyake's classification

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