大腸気腫性嚢胞症の臨床疫学的検討-trichloroethylene 使用歴との関係について-

概要

論文の詳細を見る
A case-control study of 13 cases with pneumatosis cystoides coli (PCC) was carried out to assess the association between PCC and working conditions including occupational exposure to organic solvents. The controls consisted of 65 subjects matched by sex, age and admission year to the patients with PCC. It was found that there was a close association between the development of PCC and occupational exposure to trichloroethylene (TCE).Tweleve of thirteen cases of primary PCC (92.3%) each had an occupational history of exposure to TCE, and each of 2 pairs among them had been working in the same factory. The healing and recurrence of PCC in these cases substantially paralleled their occupational exposure to TCE.A mass survey for the detection of PCC was carried out in a company where TCE was used, and failed to find any colorectal lesion.These results suggested that the long-term exposure to TCE could be one of the contributing factors for the development of PCC in subjects with susceptibility, the details of which has not been yet clarified and should be further elucidated.
財団法人日本消化器病学会の論文