Non-A, Non-B型輸血後肝炎の1例 : 原因となった供血者血液のチンパンジー接種実験

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A 49 year old woman, diagnosed Non-A, Non-B posttransfusion hepatitis (PTH), was admitted to our hospital in Decembar, 1975.<BR>Blood samples were drawn from five implicated blood donors three months after the initial donation. Their sera were pooled and inoculated to one chimpanzee. Blood chemist-ries were tested in the interval of one to two weeks and serial liver biopsies were observed over 27 weeks.<BR>The animal did not show any abnormal blood chemistries during observation periods. However liver biopsies obtained in second to 12th weeks after inoculation showed the "peculiar tubular structures" which were thought to be the marker of one type of Non-A, Non-B hepatitis (Non-A, Non-B-1) in chimpanzees.<BR>It was suspected that the subclinical infection of Non-A, Non-B hepatitis might occur in a chimpanzee.
社団法人日本肝臓学会の論文