タイトル無し

概要

論文の詳細を見る
The HDL2 fraction (1.063<d<1.125) in plasma of patients with cholestasis was separated into three subfractions (unbound, bound I and bound II) by heparin-Sepharose affinity chromatography.The unbound subfraction appeared to be spherical in a diameter of approximately 10nm, in the absence of the Apo E.Since bound I and bound II subfractions contained the Apo E, they seemed to correspond with the Apo E-rich HDL. In particular, bound II subfraction contained a significant amount of the Apo E and was observed in part the rouleaux formation. In addition, bound I and bound II subfractions contained more phospholipid and free cholesterol and less protein than those in the unbound one.On the other hand, since the bound II subfraction contained the Apo B, it was assumed to be contaminated with LDL and Lp(a).The Apo E-rich HDL was remarkably increased in plasma of patients with cholestasis. Besides the decrease of the LCAT activity, the increase of the Apo E-rich HDL may well be formed by apoproteins derived, at least in part, from extrahepatic organs and by the catabolic disturbance of the HDL which is mainly catabolized in hepatocyte via Apo E-receptor.
財団法人日本消化器病学会の論文