昏睡出現時より組織学的に観察し得た劇症肝炎の1生存例

概要

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Fulminant hepatitis due to the massive hepatic necrosis is the most serious syndrome in hepatic inflammations, exhibiting various complications such as cerebral edema, renal dysfunction and impaired blood coagulation system. It is usually difficult to examine the liver histologically during hepatic coma. In this paper, the histological changes in the liver both during and after recovery from fulminant hepatitis were described in a 59 years old woman. On the liver specimen obtained at the initial phase of coma, normal hepatic structure was diffusely destroyed, showing hepatic cell necrosis, degeneration, bleeding and inflammatory cell infiltration. Chronic hepatitis i.e. destruction of the limiting plates, and inflammatory cell infiltration was revealed on two liver biopsy specimens obtained after two and six months, respectively.