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The abnormal lipoprotein-X (LP-X) observed in patients with cholestasis was deviled into two subfractions (LP-X1 and LP-X2) by zonal ultracentrifugation. To clarify the mechanism of LP-X formation, the changes of two subfractions of LP-X and their lipid and apoprotein compositions were studied.In patients with extraheptic cholestasis LP-X1/LP-X2 ratio was increased as cholestasis progressed: LP-X1 was accumulated predominantly. And the ratio was decreased as the cholestasis reduced by PTC-drainage.On the other hand, in patients with intrahepatic cholestasis LP-X2 was markedly increased, whereas LP-X1 was not detectable. There were no significant differences in the lipid and protein compositions between LP-X1 and LP-X2. In the composition of apoproteins, however LP-X2 was abundant in Apo E which is assumed to be derived from hepatocyte.These findings suggest that LP-X1 is formed by the direct regurgitation of the bile components into the circulation and LP-X2 is synthesized and secreted by the liver.
財団法人日本消化器病学会の論文