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The First Department of Internal Medicine, Gifu University School of Medicine (Gifu) To elucidate the underlying mechanisms of appearance of abnormal lipoproteins in cholestasis, studies were conducted to investigate the molecular species of lipoprotein-X.Plasma low density lipoprotein (LDL) fraction, obtained from the patients with cholestasis, was further separated by zonal ultracentrifugation into 3 subfractions: Peak 1 (density ca. 1.04), Peak 2 (density ca. 1.07) and Peak 3 (density ca. 1.08).Since both peak 1 and 2 migrated toward the cathode by electrophoresis on Bacto agar, these fractions were proved to be molecular species of Lp-X(Lp-X1 and Lp-X2).A distinct peak of Lp-X1 and Lp-X2 was clearly observed at the advanced stage of extrahepatic cholestasis. But at the early stage of it only a small peak of Lp-X2 was detected.In the two cases of intrahepatic cholestasis, the amount of Lp-X2 was more dominant than that of extrahepatic cholestasis. On the other hand, Lp-X-like lipoproteins such as Lp-Xs formed by in vitro incubation according to the method of Manzato and Lp-Xi obtained from cirrhotic patients who received Intralipid infusion were both eluted at the position consistent with Lp-X1 peak of cholestasis.These findings strongly suggest that Lp-X1 is produced exclusively either in vitro or intravascularly, and Lp-X2 is formed through the hepatocyte during regurgitation of the bile components into the circulation.
財団法人日本消化器病学会の論文

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